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Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice
Alcoholic liver disease (ALD) is a major health problem and a significant cause of liver-related death. Currently, the mainstay for ALD therapy is alcohol abstinence highlighting the need to develop pharmacotherapeutic approaches. Protein-tyrosine phosphatase 1B (PTP1B) is an established regulator o...
Autores principales: | Hsu, Ming-Fo, Koike, Shinichiro, Mello, Aline, Nagy, Laura E., Haj, Fawaz G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408361/ https://www.ncbi.nlm.nih.gov/pubmed/32769011 http://dx.doi.org/10.1016/j.redox.2020.101658 |
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