Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites

Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds...

Descripción completa

Detalles Bibliográficos
Autores principales: Magalhães Rebelo, Ana Paula, Dal Bello, Federica, Knedlik, Tomas, Kaar, Natasha, Volpin, Fabio, Shin, Sang Hun, Giacomello, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408517/
https://www.ncbi.nlm.nih.gov/pubmed/32646031
http://dx.doi.org/10.3390/cells9071637
_version_ 1783567849595338752
author Magalhães Rebelo, Ana Paula
Dal Bello, Federica
Knedlik, Tomas
Kaar, Natasha
Volpin, Fabio
Shin, Sang Hun
Giacomello, Marta
author_facet Magalhães Rebelo, Ana Paula
Dal Bello, Federica
Knedlik, Tomas
Kaar, Natasha
Volpin, Fabio
Shin, Sang Hun
Giacomello, Marta
author_sort Magalhães Rebelo, Ana Paula
collection PubMed
description Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria–ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies.
format Online
Article
Text
id pubmed-7408517
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74085172020-08-13 Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites Magalhães Rebelo, Ana Paula Dal Bello, Federica Knedlik, Tomas Kaar, Natasha Volpin, Fabio Shin, Sang Hun Giacomello, Marta Cells Review Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria–ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies. MDPI 2020-07-07 /pmc/articles/PMC7408517/ /pubmed/32646031 http://dx.doi.org/10.3390/cells9071637 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Magalhães Rebelo, Ana Paula
Dal Bello, Federica
Knedlik, Tomas
Kaar, Natasha
Volpin, Fabio
Shin, Sang Hun
Giacomello, Marta
Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title_full Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title_fullStr Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title_full_unstemmed Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title_short Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
title_sort chemical modulation of mitochondria–endoplasmic reticulum contact sites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408517/
https://www.ncbi.nlm.nih.gov/pubmed/32646031
http://dx.doi.org/10.3390/cells9071637
work_keys_str_mv AT magalhaesrebeloanapaula chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT dalbellofederica chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT knedliktomas chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT kaarnatasha chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT volpinfabio chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT shinsanghun chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites
AT giacomellomarta chemicalmodulationofmitochondriaendoplasmicreticulumcontactsites

Ejemplares similares