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The Role of MicroRNAs in Repair Processes in Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS and currently there are no treatments to address thi...

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Detalles Bibliográficos
Autores principales: Duffy, Conor P., McCoy, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408558/
https://www.ncbi.nlm.nih.gov/pubmed/32708794
http://dx.doi.org/10.3390/cells9071711
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author Duffy, Conor P.
McCoy, Claire E.
author_facet Duffy, Conor P.
McCoy, Claire E.
author_sort Duffy, Conor P.
collection PubMed
description Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS and currently there are no treatments to address this deficit. In recent years, increasing attention has been paid to the influence of the small, non-coding RNA molecules, microRNAs (miRNAs), in autoimmune disorders, including MS. In this review, we examine the role of miRNAs in remyelination in the different cell types that contribute to MS. We focus on key miRNAs that have a central role in mediating the repair process, along with several more that play either secondary or inhibitory roles in one or more aspects. Finally, we consider the current state of miRNAs as therapeutic targets in MS, acknowledging current challenges and potential strategies to overcome them in developing effective novel therapeutics to enhance repair mechanisms in MS.
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spelling pubmed-74085582020-08-13 The Role of MicroRNAs in Repair Processes in Multiple Sclerosis Duffy, Conor P. McCoy, Claire E. Cells Review Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS and currently there are no treatments to address this deficit. In recent years, increasing attention has been paid to the influence of the small, non-coding RNA molecules, microRNAs (miRNAs), in autoimmune disorders, including MS. In this review, we examine the role of miRNAs in remyelination in the different cell types that contribute to MS. We focus on key miRNAs that have a central role in mediating the repair process, along with several more that play either secondary or inhibitory roles in one or more aspects. Finally, we consider the current state of miRNAs as therapeutic targets in MS, acknowledging current challenges and potential strategies to overcome them in developing effective novel therapeutics to enhance repair mechanisms in MS. MDPI 2020-07-16 /pmc/articles/PMC7408558/ /pubmed/32708794 http://dx.doi.org/10.3390/cells9071711 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Duffy, Conor P.
McCoy, Claire E.
The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title_full The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title_fullStr The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title_full_unstemmed The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title_short The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
title_sort role of micrornas in repair processes in multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408558/
https://www.ncbi.nlm.nih.gov/pubmed/32708794
http://dx.doi.org/10.3390/cells9071711
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