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MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408560/ https://www.ncbi.nlm.nih.gov/pubmed/32660059 http://dx.doi.org/10.3390/cells9071649 |
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author | Uray, Karen Major, Evelin Lontay, Beata |
author_facet | Uray, Karen Major, Evelin Lontay, Beata |
author_sort | Uray, Karen |
collection | PubMed |
description | MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myosin genes or indirectly on the diverse signaling cascades modulating cytoskeletal arrangement. Furthermore, studies from various human models indicate that miRNAs contribute to the development of various human disorders. The potentially huge impact of miRNA-based mechanisms on cytoskeletal elements is just starting to be recognized. In this review, we summarize recent knowledge about the importance of microRNA modulation of the actin–myosin cytoskeleton affecting physiological processes, including cardiovascular function, hematopoiesis, podocyte physiology, and osteogenesis. |
format | Online Article Text |
id | pubmed-7408560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74085602020-08-13 MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton Uray, Karen Major, Evelin Lontay, Beata Cells Review MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myosin genes or indirectly on the diverse signaling cascades modulating cytoskeletal arrangement. Furthermore, studies from various human models indicate that miRNAs contribute to the development of various human disorders. The potentially huge impact of miRNA-based mechanisms on cytoskeletal elements is just starting to be recognized. In this review, we summarize recent knowledge about the importance of microRNA modulation of the actin–myosin cytoskeleton affecting physiological processes, including cardiovascular function, hematopoiesis, podocyte physiology, and osteogenesis. MDPI 2020-07-09 /pmc/articles/PMC7408560/ /pubmed/32660059 http://dx.doi.org/10.3390/cells9071649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Uray, Karen Major, Evelin Lontay, Beata MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title | MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title_full | MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title_fullStr | MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title_full_unstemmed | MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title_short | MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton |
title_sort | microrna regulatory pathways in the control of the actin–myosin cytoskeleton |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408560/ https://www.ncbi.nlm.nih.gov/pubmed/32660059 http://dx.doi.org/10.3390/cells9071649 |
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