Cargando…

MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton

MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myo...

Descripción completa

Detalles Bibliográficos
Autores principales: Uray, Karen, Major, Evelin, Lontay, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408560/
https://www.ncbi.nlm.nih.gov/pubmed/32660059
http://dx.doi.org/10.3390/cells9071649
_version_ 1783567859337658368
author Uray, Karen
Major, Evelin
Lontay, Beata
author_facet Uray, Karen
Major, Evelin
Lontay, Beata
author_sort Uray, Karen
collection PubMed
description MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myosin genes or indirectly on the diverse signaling cascades modulating cytoskeletal arrangement. Furthermore, studies from various human models indicate that miRNAs contribute to the development of various human disorders. The potentially huge impact of miRNA-based mechanisms on cytoskeletal elements is just starting to be recognized. In this review, we summarize recent knowledge about the importance of microRNA modulation of the actin–myosin cytoskeleton affecting physiological processes, including cardiovascular function, hematopoiesis, podocyte physiology, and osteogenesis.
format Online
Article
Text
id pubmed-7408560
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74085602020-08-13 MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton Uray, Karen Major, Evelin Lontay, Beata Cells Review MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics. Recent evidence points to the widespread effects of miRNAs on actin–myosin cytoskeleton dynamics, either directly on the expression of actin and myosin genes or indirectly on the diverse signaling cascades modulating cytoskeletal arrangement. Furthermore, studies from various human models indicate that miRNAs contribute to the development of various human disorders. The potentially huge impact of miRNA-based mechanisms on cytoskeletal elements is just starting to be recognized. In this review, we summarize recent knowledge about the importance of microRNA modulation of the actin–myosin cytoskeleton affecting physiological processes, including cardiovascular function, hematopoiesis, podocyte physiology, and osteogenesis. MDPI 2020-07-09 /pmc/articles/PMC7408560/ /pubmed/32660059 http://dx.doi.org/10.3390/cells9071649 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Uray, Karen
Major, Evelin
Lontay, Beata
MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title_full MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title_fullStr MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title_full_unstemmed MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title_short MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton
title_sort microrna regulatory pathways in the control of the actin–myosin cytoskeleton
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408560/
https://www.ncbi.nlm.nih.gov/pubmed/32660059
http://dx.doi.org/10.3390/cells9071649
work_keys_str_mv AT uraykaren micrornaregulatorypathwaysinthecontroloftheactinmyosincytoskeleton
AT majorevelin micrornaregulatorypathwaysinthecontroloftheactinmyosincytoskeleton
AT lontaybeata micrornaregulatorypathwaysinthecontroloftheactinmyosincytoskeleton