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The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis

Although antimicrobial therapy is recommended for patients with moderate or severe ischemic colitis, its beneficial effects are unclear. In the present study, the role of antimicrobial therapy in the treatment of ischemic colitis was investigated. Patients with ischemic colitis were retrospectively...

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Autores principales: Lee, Jae Gon, Park, Jin Hwa, Han, Dong Soo, Lee, Hang Lak, Park, Chan Hyuk, Eun, Chang Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408655/
https://www.ncbi.nlm.nih.gov/pubmed/32664298
http://dx.doi.org/10.3390/jcm9072182
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author Lee, Jae Gon
Park, Jin Hwa
Han, Dong Soo
Lee, Hang Lak
Park, Chan Hyuk
Eun, Chang Soo
author_facet Lee, Jae Gon
Park, Jin Hwa
Han, Dong Soo
Lee, Hang Lak
Park, Chan Hyuk
Eun, Chang Soo
author_sort Lee, Jae Gon
collection PubMed
description Although antimicrobial therapy is recommended for patients with moderate or severe ischemic colitis, its beneficial effects are unclear. In the present study, the role of antimicrobial therapy in the treatment of ischemic colitis was investigated. Patients with ischemic colitis were retrospectively identified between January 2004 and June 2019. The characteristics and outcomes of patients who received antibiotics (antibiotics group) and those who did not (no-antibiotics group) were compared. Clinical outcomes included death, surgery, and readmission within 30 days, fasting duration, and hospital stay. Data from 186 patients were analyzed; 122 patients were in the antibiotics group and 64 in the no-antibiotics group. Composite outcome of death, surgery, and readmission within 30 days occurred in 3.3% of patients in the antibiotics group and 3.1% of patients in the no-antibiotics group (p > 0.999). Fasting duration was not significantly different between the two groups (median days, 4.0 vs. 4.0, p = 0.253). However, hospital stays were longer in the antibiotics group than in the no-antibiotics group (median days, 9.0 vs. 7.0, p = 0.043). In patients with ischemic colitis, there was no statistically significant difference in the incidence of death, surgery, and readmission within 30 days between patients who received antibiotics and those who did not receive antibiotics.
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spelling pubmed-74086552020-08-13 The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis Lee, Jae Gon Park, Jin Hwa Han, Dong Soo Lee, Hang Lak Park, Chan Hyuk Eun, Chang Soo J Clin Med Article Although antimicrobial therapy is recommended for patients with moderate or severe ischemic colitis, its beneficial effects are unclear. In the present study, the role of antimicrobial therapy in the treatment of ischemic colitis was investigated. Patients with ischemic colitis were retrospectively identified between January 2004 and June 2019. The characteristics and outcomes of patients who received antibiotics (antibiotics group) and those who did not (no-antibiotics group) were compared. Clinical outcomes included death, surgery, and readmission within 30 days, fasting duration, and hospital stay. Data from 186 patients were analyzed; 122 patients were in the antibiotics group and 64 in the no-antibiotics group. Composite outcome of death, surgery, and readmission within 30 days occurred in 3.3% of patients in the antibiotics group and 3.1% of patients in the no-antibiotics group (p > 0.999). Fasting duration was not significantly different between the two groups (median days, 4.0 vs. 4.0, p = 0.253). However, hospital stays were longer in the antibiotics group than in the no-antibiotics group (median days, 9.0 vs. 7.0, p = 0.043). In patients with ischemic colitis, there was no statistically significant difference in the incidence of death, surgery, and readmission within 30 days between patients who received antibiotics and those who did not receive antibiotics. MDPI 2020-07-10 /pmc/articles/PMC7408655/ /pubmed/32664298 http://dx.doi.org/10.3390/jcm9072182 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Jae Gon
Park, Jin Hwa
Han, Dong Soo
Lee, Hang Lak
Park, Chan Hyuk
Eun, Chang Soo
The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title_full The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title_fullStr The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title_full_unstemmed The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title_short The Uncertain Effect of Antimicrobial Therapy in the Treatment of Patients with Ischemic Colitis
title_sort uncertain effect of antimicrobial therapy in the treatment of patients with ischemic colitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408655/
https://www.ncbi.nlm.nih.gov/pubmed/32664298
http://dx.doi.org/10.3390/jcm9072182
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