Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression

Background: Pancreatic ductal adenocarcinoma (PDAC) is resistant to single-agent immunotherapies. To understand the mechanisms leading to the poor response to this treatment, a better understanding of the PDAC immune landscape is required. The present work aims to study the immune profile in PDAC in...

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Detalles Bibliográficos
Autores principales: Papalampros, Alexandros, Vailas, Michail, Ntostoglou, Konstantinos, Chiloeches, Maria Lopez, Sakellariou, Stratigoula, Chouliari, Niki V., Samaras, Menelaos G., Veltsista, Paraskevi D., Theodorou, Sofia D. P., Margetis, Aggelos T., Bergonzini, Anna, Karydakis, Lysandros, Hasemaki, Natasha, Havaki, Sophia, Moustakas, Ioannis I., Chatzigeorgiou, Antonios, Karamitros, Timokratis, Patsea, Eleni, Kittas, Christos, Lazaris, Andreas C., Felekouras, Evangelos, Gorgoulis, Vassilis G., Frisan, Teresa, Pateras, Ioannis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408661/
https://www.ncbi.nlm.nih.gov/pubmed/32645996
http://dx.doi.org/10.3390/cancers12071825

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