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A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic ha...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408697/ https://www.ncbi.nlm.nih.gov/pubmed/32664343 http://dx.doi.org/10.3390/cancers12071863 |
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author | Pinto, Mauricio P. Córdova-Delgado, Miguel Retamal, Ignacio N. Muñoz-Medel, Matías Bravo, M. Loreto Durán, Doris Villanueva, Francisco Sanchez, César Acevedo, Francisco Mondaca, Sebastián Koch, Erica Ibañez, Carolina Galindo, Héctor Madrid, Jorge Nervi, Bruno Peña, José Torres, Javiera Owen, Gareth I. Corvalán, Alejandro H. Armisén, Ricardo Garrido, Marcelo |
author_facet | Pinto, Mauricio P. Córdova-Delgado, Miguel Retamal, Ignacio N. Muñoz-Medel, Matías Bravo, M. Loreto Durán, Doris Villanueva, Francisco Sanchez, César Acevedo, Francisco Mondaca, Sebastián Koch, Erica Ibañez, Carolina Galindo, Héctor Madrid, Jorge Nervi, Bruno Peña, José Torres, Javiera Owen, Gareth I. Corvalán, Alejandro H. Armisén, Ricardo Garrido, Marcelo |
author_sort | Pinto, Mauricio P. |
collection | PubMed |
description | Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtypes, based on immunohistochemical (IHC) and in situ hybridization (ISH) methods. These were Epstein–Barr virus positive (EBV+), mismatch repair-deficient (MMR-D), epithelial to mesenchymal transition (EMT)-like, and accumulated (p53+) or undetected p53 (p53−). Given its lower costs this system has the potential for clinical applicability. Our results confirm relevant molecular alterations previously reported by TCGA and ACRG. We confirm EBV+ and MMR-D patients had the best prognosis and could be candidates for immunotherapy. Conversely, EMT-like displayed the poorest prognosis; our data suggest FGFR2 or KRAS could serve as potential actionable targets for these patients. Finally, we propose a low-cost step-by-step stratification system for GC patients. To the best of our knowledge, this is the first Latin American report on a molecular classification for GC. Pending further validation, this stratification system could be implemented into the routine clinic |
format | Online Article Text |
id | pubmed-7408697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74086972020-08-13 A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability Pinto, Mauricio P. Córdova-Delgado, Miguel Retamal, Ignacio N. Muñoz-Medel, Matías Bravo, M. Loreto Durán, Doris Villanueva, Francisco Sanchez, César Acevedo, Francisco Mondaca, Sebastián Koch, Erica Ibañez, Carolina Galindo, Héctor Madrid, Jorge Nervi, Bruno Peña, José Torres, Javiera Owen, Gareth I. Corvalán, Alejandro H. Armisén, Ricardo Garrido, Marcelo Cancers (Basel) Article Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtypes, based on immunohistochemical (IHC) and in situ hybridization (ISH) methods. These were Epstein–Barr virus positive (EBV+), mismatch repair-deficient (MMR-D), epithelial to mesenchymal transition (EMT)-like, and accumulated (p53+) or undetected p53 (p53−). Given its lower costs this system has the potential for clinical applicability. Our results confirm relevant molecular alterations previously reported by TCGA and ACRG. We confirm EBV+ and MMR-D patients had the best prognosis and could be candidates for immunotherapy. Conversely, EMT-like displayed the poorest prognosis; our data suggest FGFR2 or KRAS could serve as potential actionable targets for these patients. Finally, we propose a low-cost step-by-step stratification system for GC patients. To the best of our knowledge, this is the first Latin American report on a molecular classification for GC. Pending further validation, this stratification system could be implemented into the routine clinic MDPI 2020-07-10 /pmc/articles/PMC7408697/ /pubmed/32664343 http://dx.doi.org/10.3390/cancers12071863 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pinto, Mauricio P. Córdova-Delgado, Miguel Retamal, Ignacio N. Muñoz-Medel, Matías Bravo, M. Loreto Durán, Doris Villanueva, Francisco Sanchez, César Acevedo, Francisco Mondaca, Sebastián Koch, Erica Ibañez, Carolina Galindo, Héctor Madrid, Jorge Nervi, Bruno Peña, José Torres, Javiera Owen, Gareth I. Corvalán, Alejandro H. Armisén, Ricardo Garrido, Marcelo A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title | A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title_full | A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title_fullStr | A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title_full_unstemmed | A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title_short | A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability |
title_sort | molecular stratification of chilean gastric cancer patients with potential clinical applicability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408697/ https://www.ncbi.nlm.nih.gov/pubmed/32664343 http://dx.doi.org/10.3390/cancers12071863 |
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