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A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability

Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic ha...

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Autores principales: Pinto, Mauricio P., Córdova-Delgado, Miguel, Retamal, Ignacio N., Muñoz-Medel, Matías, Bravo, M. Loreto, Durán, Doris, Villanueva, Francisco, Sanchez, César, Acevedo, Francisco, Mondaca, Sebastián, Koch, Erica, Ibañez, Carolina, Galindo, Héctor, Madrid, Jorge, Nervi, Bruno, Peña, José, Torres, Javiera, Owen, Gareth I., Corvalán, Alejandro H., Armisén, Ricardo, Garrido, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408697/
https://www.ncbi.nlm.nih.gov/pubmed/32664343
http://dx.doi.org/10.3390/cancers12071863
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author Pinto, Mauricio P.
Córdova-Delgado, Miguel
Retamal, Ignacio N.
Muñoz-Medel, Matías
Bravo, M. Loreto
Durán, Doris
Villanueva, Francisco
Sanchez, César
Acevedo, Francisco
Mondaca, Sebastián
Koch, Erica
Ibañez, Carolina
Galindo, Héctor
Madrid, Jorge
Nervi, Bruno
Peña, José
Torres, Javiera
Owen, Gareth I.
Corvalán, Alejandro H.
Armisén, Ricardo
Garrido, Marcelo
author_facet Pinto, Mauricio P.
Córdova-Delgado, Miguel
Retamal, Ignacio N.
Muñoz-Medel, Matías
Bravo, M. Loreto
Durán, Doris
Villanueva, Francisco
Sanchez, César
Acevedo, Francisco
Mondaca, Sebastián
Koch, Erica
Ibañez, Carolina
Galindo, Héctor
Madrid, Jorge
Nervi, Bruno
Peña, José
Torres, Javiera
Owen, Gareth I.
Corvalán, Alejandro H.
Armisén, Ricardo
Garrido, Marcelo
author_sort Pinto, Mauricio P.
collection PubMed
description Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtypes, based on immunohistochemical (IHC) and in situ hybridization (ISH) methods. These were Epstein–Barr virus positive (EBV+), mismatch repair-deficient (MMR-D), epithelial to mesenchymal transition (EMT)-like, and accumulated (p53+) or undetected p53 (p53−). Given its lower costs this system has the potential for clinical applicability. Our results confirm relevant molecular alterations previously reported by TCGA and ACRG. We confirm EBV+ and MMR-D patients had the best prognosis and could be candidates for immunotherapy. Conversely, EMT-like displayed the poorest prognosis; our data suggest FGFR2 or KRAS could serve as potential actionable targets for these patients. Finally, we propose a low-cost step-by-step stratification system for GC patients. To the best of our knowledge, this is the first Latin American report on a molecular classification for GC. Pending further validation, this stratification system could be implemented into the routine clinic
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spelling pubmed-74086972020-08-13 A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability Pinto, Mauricio P. Córdova-Delgado, Miguel Retamal, Ignacio N. Muñoz-Medel, Matías Bravo, M. Loreto Durán, Doris Villanueva, Francisco Sanchez, César Acevedo, Francisco Mondaca, Sebastián Koch, Erica Ibañez, Carolina Galindo, Héctor Madrid, Jorge Nervi, Bruno Peña, José Torres, Javiera Owen, Gareth I. Corvalán, Alejandro H. Armisén, Ricardo Garrido, Marcelo Cancers (Basel) Article Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtypes, based on immunohistochemical (IHC) and in situ hybridization (ISH) methods. These were Epstein–Barr virus positive (EBV+), mismatch repair-deficient (MMR-D), epithelial to mesenchymal transition (EMT)-like, and accumulated (p53+) or undetected p53 (p53−). Given its lower costs this system has the potential for clinical applicability. Our results confirm relevant molecular alterations previously reported by TCGA and ACRG. We confirm EBV+ and MMR-D patients had the best prognosis and could be candidates for immunotherapy. Conversely, EMT-like displayed the poorest prognosis; our data suggest FGFR2 or KRAS could serve as potential actionable targets for these patients. Finally, we propose a low-cost step-by-step stratification system for GC patients. To the best of our knowledge, this is the first Latin American report on a molecular classification for GC. Pending further validation, this stratification system could be implemented into the routine clinic MDPI 2020-07-10 /pmc/articles/PMC7408697/ /pubmed/32664343 http://dx.doi.org/10.3390/cancers12071863 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pinto, Mauricio P.
Córdova-Delgado, Miguel
Retamal, Ignacio N.
Muñoz-Medel, Matías
Bravo, M. Loreto
Durán, Doris
Villanueva, Francisco
Sanchez, César
Acevedo, Francisco
Mondaca, Sebastián
Koch, Erica
Ibañez, Carolina
Galindo, Héctor
Madrid, Jorge
Nervi, Bruno
Peña, José
Torres, Javiera
Owen, Gareth I.
Corvalán, Alejandro H.
Armisén, Ricardo
Garrido, Marcelo
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title_full A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title_fullStr A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title_full_unstemmed A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title_short A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
title_sort molecular stratification of chilean gastric cancer patients with potential clinical applicability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408697/
https://www.ncbi.nlm.nih.gov/pubmed/32664343
http://dx.doi.org/10.3390/cancers12071863
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