Cargando…

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

Metastatic colorectal cancer (mCRC) remains challenging because of the emergence of resistance mechanisms to anti-epidermal growth factor receptor (EGFR) therapeutics, so more effective strategies to improve the patients’ outcome are needed. During the last decade, the application of a multi-omics a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Porru, Manuela, Zizza, Pasquale, Panera, Nadia, Alisi, Anna, Biroccio, Annamaria, Leonetti, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408740/ https://www.ncbi.nlm.nih.gov/pubmed/32650388 http://dx.doi.org/10.3390/cancers12071830

Ejemplares similares

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities
por: Porru, Manuela, et al.
Publicado: (2018)

Patient-derived xenografts: a relevant preclinical model for drug development
por: Pompili, Luca, et al.
Publicado: (2016)

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
por: Rizzo, Angela, et al.
Publicado: (2014)

Erratum: Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
por: Rizzo, Angela, et al.
Publicado: (2015)

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds
por: Salvati, Erica, et al.
Publicado: (2015)

TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients
por: Dinami, Roberto, et al.
Publicado: (2020)

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
por: Pompili, Luca, et al.
Publicado: (2017)

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance
por: Zizza, Pasquale, et al.
Publicado: (2016)

A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy
por: Cherfils-Vicini, Julien, et al.
Publicado: (2014)

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis
por: Salvati, Erica, et al.
Publicado: (2014)

Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children
por: Alisi, Anna, et al.
Publicado: (2011)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
por: Zizza, Pasquale, et al.
Publicado: (2019)

The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
por: Panera, Nadia, et al.
Publicado: (2020)

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts
por: Iachettini, Sara, et al.
Publicado: (2013)

Drug repositioning strategy for the identification of novel telomere‐damaging agents: A role for NAMPT inhibitors
por: Rizzo, Angela, et al.
Publicado: (2023)

Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis
por: Alisi, Anna, et al.
Publicado: (2012)

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
por: Iachettini, Sara, et al.
Publicado: (2018)

Is obesity in childhood protective for breast cancer in young women?
por: D’Ermo, Giuseppe, et al.
Publicado: (2019)

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours
por: Groelly, Florian J, et al.
Publicado: (2022)

Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma
por: Panera, Nadia, et al.
Publicado: (2017)

Arterial Stiffness, Thickness and Association to Suitable Novel Markers of Risk at the Origin of Cardiovascular Disease in Obese Children
por: Manco, Melania, et al.
Publicado: (2017)

Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography
por: Platella, Chiara, et al.
Publicado: (2020)

Genetics, epigenetics and transgenerational transmission of obesity in children
por: Panera, Nadia, et al.
Publicado: (2022)

Harnessing the therapeutic vulnerability of MMR heterogeneity in colorectal cancer
por: Anandappa, Gayathri, et al.
Publicado: (2023)

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2
por: Gnani, Daniela, et al.
Publicado: (2017)

Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects
por: Romito, Ilaria, et al.
Publicado: (2021)

Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects
por: Romito, Ilaria, et al.
Publicado: (2022)

The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy
por: Iachettini, Sara, et al.
Publicado: (2022)

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis
por: Salvati, E., et al.
Publicado: (2014)

Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
por: Xie, Frank Y., et al.
Publicado: (2006)

Harnessing preclinical models for the interrogation of ovarian cancer
por: Qin, Tianyu, et al.
Publicado: (2022)

Biomarker discovery for chronic liver diseases by multi-omics – a preclinical case study
por: Veyel, Daniel, et al.
Publicado: (2020)

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex
por: Amato, Jussara, et al.
Publicado: (2014)

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
por: Alisi, Anna, et al.
Publicado: (2017)

The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
por: Mosca, Antonella, et al.
Publicado: (2022)

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft
por: Spugnini, Enrico P, et al.
Publicado: (2011)

Plasma Levels of Homocysteine and Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage
por: Pastore, Anna, et al.
Publicado: (2014)

Selective Targeting of Cancer-Related G-Quadruplex Structures by the Natural Compound Dicentrine
por: Platella, Chiara, et al.
Publicado: (2023)

Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD
por: Alisi, Anna, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ibapqe4l8lus4nd2kecqe8jm39