Cargando…
Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408753/ https://www.ncbi.nlm.nih.gov/pubmed/32674456 http://dx.doi.org/10.3390/jcm9072236 |
_version_ | 1783567904663404544 |
---|---|
author | Yu, Jihion Hong, Bumsik Park, Jun-Young Lee, Yongsoo Hwang, Jai-Hyun Kong, Yu-Gyeong Kim, Young-Kug |
author_facet | Yu, Jihion Hong, Bumsik Park, Jun-Young Lee, Yongsoo Hwang, Jai-Hyun Kong, Yu-Gyeong Kim, Young-Kug |
author_sort | Yu, Jihion |
collection | PubMed |
description | Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant GFR decline between ileal conduit and ileal neobladder urinary diversions 12 months after radical cystectomy. We retrospectively included radical cystectomy patients. Propensity score-matched analysis was performed. The primary outcome was the incidence of a significant GFR decline in ileal conduit urinary diversion (ileal conduit group) and ileal neobladder urinary diversion (ileal neobladder group) 12 months after radical cystectomy. The secondary outcomes were the change of GFR and the incidence of end-stage renal disease (ESRD) in the two groups. After propensity score matching, the ileal conduit and neobladder groups had 117 patients each. The incidence of a significant GFR decline was not significantly different between ileal conduit and ileal neobladder groups (12.0% vs. 13.7%, p = 0.845). The change of GFR and ESRD incidence were not significantly different between the two groups (−8.4% vs. −9.7%, p = 0.480; 4.3% vs. 5.1%, p > 0.999, respectively). These results can provide important information on appropriate selection of the urinary diversion type in radical cystectomy. |
format | Online Article Text |
id | pubmed-7408753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74087532020-08-13 Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis Yu, Jihion Hong, Bumsik Park, Jun-Young Lee, Yongsoo Hwang, Jai-Hyun Kong, Yu-Gyeong Kim, Young-Kug J Clin Med Article Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant GFR decline between ileal conduit and ileal neobladder urinary diversions 12 months after radical cystectomy. We retrospectively included radical cystectomy patients. Propensity score-matched analysis was performed. The primary outcome was the incidence of a significant GFR decline in ileal conduit urinary diversion (ileal conduit group) and ileal neobladder urinary diversion (ileal neobladder group) 12 months after radical cystectomy. The secondary outcomes were the change of GFR and the incidence of end-stage renal disease (ESRD) in the two groups. After propensity score matching, the ileal conduit and neobladder groups had 117 patients each. The incidence of a significant GFR decline was not significantly different between ileal conduit and ileal neobladder groups (12.0% vs. 13.7%, p = 0.845). The change of GFR and ESRD incidence were not significantly different between the two groups (−8.4% vs. −9.7%, p = 0.480; 4.3% vs. 5.1%, p > 0.999, respectively). These results can provide important information on appropriate selection of the urinary diversion type in radical cystectomy. MDPI 2020-07-14 /pmc/articles/PMC7408753/ /pubmed/32674456 http://dx.doi.org/10.3390/jcm9072236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yu, Jihion Hong, Bumsik Park, Jun-Young Lee, Yongsoo Hwang, Jai-Hyun Kong, Yu-Gyeong Kim, Young-Kug Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title | Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title_full | Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title_fullStr | Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title_full_unstemmed | Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title_short | Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis |
title_sort | comparison of a significant decline in the glomerular filtration rate between ileal conduit and ileal neobladder urinary diversions after radical cystectomy: a propensity score-matched analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408753/ https://www.ncbi.nlm.nih.gov/pubmed/32674456 http://dx.doi.org/10.3390/jcm9072236 |
work_keys_str_mv | AT yujihion comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT hongbumsik comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT parkjunyoung comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT leeyongsoo comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT hwangjaihyun comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT kongyugyeong comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis AT kimyoungkug comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis |