Cargando…

Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis

Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Jihion, Hong, Bumsik, Park, Jun-Young, Lee, Yongsoo, Hwang, Jai-Hyun, Kong, Yu-Gyeong, Kim, Young-Kug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408753/
https://www.ncbi.nlm.nih.gov/pubmed/32674456
http://dx.doi.org/10.3390/jcm9072236
_version_ 1783567904663404544
author Yu, Jihion
Hong, Bumsik
Park, Jun-Young
Lee, Yongsoo
Hwang, Jai-Hyun
Kong, Yu-Gyeong
Kim, Young-Kug
author_facet Yu, Jihion
Hong, Bumsik
Park, Jun-Young
Lee, Yongsoo
Hwang, Jai-Hyun
Kong, Yu-Gyeong
Kim, Young-Kug
author_sort Yu, Jihion
collection PubMed
description Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant GFR decline between ileal conduit and ileal neobladder urinary diversions 12 months after radical cystectomy. We retrospectively included radical cystectomy patients. Propensity score-matched analysis was performed. The primary outcome was the incidence of a significant GFR decline in ileal conduit urinary diversion (ileal conduit group) and ileal neobladder urinary diversion (ileal neobladder group) 12 months after radical cystectomy. The secondary outcomes were the change of GFR and the incidence of end-stage renal disease (ESRD) in the two groups. After propensity score matching, the ileal conduit and neobladder groups had 117 patients each. The incidence of a significant GFR decline was not significantly different between ileal conduit and ileal neobladder groups (12.0% vs. 13.7%, p = 0.845). The change of GFR and ESRD incidence were not significantly different between the two groups (−8.4% vs. −9.7%, p = 0.480; 4.3% vs. 5.1%, p > 0.999, respectively). These results can provide important information on appropriate selection of the urinary diversion type in radical cystectomy.
format Online
Article
Text
id pubmed-7408753
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74087532020-08-13 Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis Yu, Jihion Hong, Bumsik Park, Jun-Young Lee, Yongsoo Hwang, Jai-Hyun Kong, Yu-Gyeong Kim, Young-Kug J Clin Med Article Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration rate (GFR) (i.e., a ≥30% decline in baseline GFR after 12 months) is associated with long-term renal function impairment. We compared the significant GFR decline between ileal conduit and ileal neobladder urinary diversions 12 months after radical cystectomy. We retrospectively included radical cystectomy patients. Propensity score-matched analysis was performed. The primary outcome was the incidence of a significant GFR decline in ileal conduit urinary diversion (ileal conduit group) and ileal neobladder urinary diversion (ileal neobladder group) 12 months after radical cystectomy. The secondary outcomes were the change of GFR and the incidence of end-stage renal disease (ESRD) in the two groups. After propensity score matching, the ileal conduit and neobladder groups had 117 patients each. The incidence of a significant GFR decline was not significantly different between ileal conduit and ileal neobladder groups (12.0% vs. 13.7%, p = 0.845). The change of GFR and ESRD incidence were not significantly different between the two groups (−8.4% vs. −9.7%, p = 0.480; 4.3% vs. 5.1%, p > 0.999, respectively). These results can provide important information on appropriate selection of the urinary diversion type in radical cystectomy. MDPI 2020-07-14 /pmc/articles/PMC7408753/ /pubmed/32674456 http://dx.doi.org/10.3390/jcm9072236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Jihion
Hong, Bumsik
Park, Jun-Young
Lee, Yongsoo
Hwang, Jai-Hyun
Kong, Yu-Gyeong
Kim, Young-Kug
Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title_full Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title_fullStr Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title_full_unstemmed Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title_short Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis
title_sort comparison of a significant decline in the glomerular filtration rate between ileal conduit and ileal neobladder urinary diversions after radical cystectomy: a propensity score-matched analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408753/
https://www.ncbi.nlm.nih.gov/pubmed/32674456
http://dx.doi.org/10.3390/jcm9072236
work_keys_str_mv AT yujihion comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT hongbumsik comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT parkjunyoung comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT leeyongsoo comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT hwangjaihyun comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT kongyugyeong comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis
AT kimyoungkug comparisonofasignificantdeclineintheglomerularfiltrationratebetweenilealconduitandilealneobladderurinarydiversionsafterradicalcystectomyapropensityscorematchedanalysis