Cargando…

Child–Adult Transition in Sarcoidosis: A Series of 52 Patients

(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoido...

Descripción completa

Detalles Bibliográficos
Autores principales: Chauveau, Simon, Jeny, Florence, Montagne, Marie-Emeline, Abou Taam, Rola, Houdouin, Véronique, Meinzer, Ulrich, Delacourt, Christophe, Epaud, Ralph, Cohen Aubart, Fleur, Chapelon-Abric, Catherine, Israël-Biet, Dominique, Juvin, Karine, Dossier, Antoine, Bodaghi, Bahram, Prévot, Grégoire, Naccache, Jean-Marc, Mattioni, Sarah, Deschildre, Antoine, Brouard, Jacques, Tazi, Abdellatif, Meckenstock, Roderich, Didier, Morgane, Haroche, Julien, Clement, Annick, Bernaudin, Jean-François, Nunes, Hilario, Valeyre, Dominique, Nathan, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408766/
https://www.ncbi.nlm.nih.gov/pubmed/32635292
http://dx.doi.org/10.3390/jcm9072097
_version_ 1783567907867852800
author Chauveau, Simon
Jeny, Florence
Montagne, Marie-Emeline
Abou Taam, Rola
Houdouin, Véronique
Meinzer, Ulrich
Delacourt, Christophe
Epaud, Ralph
Cohen Aubart, Fleur
Chapelon-Abric, Catherine
Israël-Biet, Dominique
Juvin, Karine
Dossier, Antoine
Bodaghi, Bahram
Prévot, Grégoire
Naccache, Jean-Marc
Mattioni, Sarah
Deschildre, Antoine
Brouard, Jacques
Tazi, Abdellatif
Meckenstock, Roderich
Didier, Morgane
Haroche, Julien
Clement, Annick
Bernaudin, Jean-François
Nunes, Hilario
Valeyre, Dominique
Nathan, Nadia
author_facet Chauveau, Simon
Jeny, Florence
Montagne, Marie-Emeline
Abou Taam, Rola
Houdouin, Véronique
Meinzer, Ulrich
Delacourt, Christophe
Epaud, Ralph
Cohen Aubart, Fleur
Chapelon-Abric, Catherine
Israël-Biet, Dominique
Juvin, Karine
Dossier, Antoine
Bodaghi, Bahram
Prévot, Grégoire
Naccache, Jean-Marc
Mattioni, Sarah
Deschildre, Antoine
Brouard, Jacques
Tazi, Abdellatif
Meckenstock, Roderich
Didier, Morgane
Haroche, Julien
Clement, Annick
Bernaudin, Jean-François
Nunes, Hilario
Valeyre, Dominique
Nathan, Nadia
author_sort Chauveau, Simon
collection PubMed
description (1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.
format Online
Article
Text
id pubmed-7408766
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74087662020-08-13 Child–Adult Transition in Sarcoidosis: A Series of 52 Patients Chauveau, Simon Jeny, Florence Montagne, Marie-Emeline Abou Taam, Rola Houdouin, Véronique Meinzer, Ulrich Delacourt, Christophe Epaud, Ralph Cohen Aubart, Fleur Chapelon-Abric, Catherine Israël-Biet, Dominique Juvin, Karine Dossier, Antoine Bodaghi, Bahram Prévot, Grégoire Naccache, Jean-Marc Mattioni, Sarah Deschildre, Antoine Brouard, Jacques Tazi, Abdellatif Meckenstock, Roderich Didier, Morgane Haroche, Julien Clement, Annick Bernaudin, Jean-François Nunes, Hilario Valeyre, Dominique Nathan, Nadia J Clin Med Article (1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood. MDPI 2020-07-03 /pmc/articles/PMC7408766/ /pubmed/32635292 http://dx.doi.org/10.3390/jcm9072097 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chauveau, Simon
Jeny, Florence
Montagne, Marie-Emeline
Abou Taam, Rola
Houdouin, Véronique
Meinzer, Ulrich
Delacourt, Christophe
Epaud, Ralph
Cohen Aubart, Fleur
Chapelon-Abric, Catherine
Israël-Biet, Dominique
Juvin, Karine
Dossier, Antoine
Bodaghi, Bahram
Prévot, Grégoire
Naccache, Jean-Marc
Mattioni, Sarah
Deschildre, Antoine
Brouard, Jacques
Tazi, Abdellatif
Meckenstock, Roderich
Didier, Morgane
Haroche, Julien
Clement, Annick
Bernaudin, Jean-François
Nunes, Hilario
Valeyre, Dominique
Nathan, Nadia
Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title_full Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title_fullStr Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title_full_unstemmed Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title_short Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
title_sort child–adult transition in sarcoidosis: a series of 52 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408766/
https://www.ncbi.nlm.nih.gov/pubmed/32635292
http://dx.doi.org/10.3390/jcm9072097
work_keys_str_mv AT chauveausimon childadulttransitioninsarcoidosisaseriesof52patients
AT jenyflorence childadulttransitioninsarcoidosisaseriesof52patients
AT montagnemarieemeline childadulttransitioninsarcoidosisaseriesof52patients
AT aboutaamrola childadulttransitioninsarcoidosisaseriesof52patients
AT houdouinveronique childadulttransitioninsarcoidosisaseriesof52patients
AT meinzerulrich childadulttransitioninsarcoidosisaseriesof52patients
AT delacourtchristophe childadulttransitioninsarcoidosisaseriesof52patients
AT epaudralph childadulttransitioninsarcoidosisaseriesof52patients
AT cohenaubartfleur childadulttransitioninsarcoidosisaseriesof52patients
AT chapelonabriccatherine childadulttransitioninsarcoidosisaseriesof52patients
AT israelbietdominique childadulttransitioninsarcoidosisaseriesof52patients
AT juvinkarine childadulttransitioninsarcoidosisaseriesof52patients
AT dossierantoine childadulttransitioninsarcoidosisaseriesof52patients
AT bodaghibahram childadulttransitioninsarcoidosisaseriesof52patients
AT prevotgregoire childadulttransitioninsarcoidosisaseriesof52patients
AT naccachejeanmarc childadulttransitioninsarcoidosisaseriesof52patients
AT mattionisarah childadulttransitioninsarcoidosisaseriesof52patients
AT deschildreantoine childadulttransitioninsarcoidosisaseriesof52patients
AT brouardjacques childadulttransitioninsarcoidosisaseriesof52patients
AT taziabdellatif childadulttransitioninsarcoidosisaseriesof52patients
AT meckenstockroderich childadulttransitioninsarcoidosisaseriesof52patients
AT didiermorgane childadulttransitioninsarcoidosisaseriesof52patients
AT harochejulien childadulttransitioninsarcoidosisaseriesof52patients
AT clementannick childadulttransitioninsarcoidosisaseriesof52patients
AT bernaudinjeanfrancois childadulttransitioninsarcoidosisaseriesof52patients
AT nuneshilario childadulttransitioninsarcoidosisaseriesof52patients
AT valeyredominique childadulttransitioninsarcoidosisaseriesof52patients
AT nathannadia childadulttransitioninsarcoidosisaseriesof52patients
AT childadulttransitioninsarcoidosisaseriesof52patients