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Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoido...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408766/ https://www.ncbi.nlm.nih.gov/pubmed/32635292 http://dx.doi.org/10.3390/jcm9072097 |
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author | Chauveau, Simon Jeny, Florence Montagne, Marie-Emeline Abou Taam, Rola Houdouin, Véronique Meinzer, Ulrich Delacourt, Christophe Epaud, Ralph Cohen Aubart, Fleur Chapelon-Abric, Catherine Israël-Biet, Dominique Juvin, Karine Dossier, Antoine Bodaghi, Bahram Prévot, Grégoire Naccache, Jean-Marc Mattioni, Sarah Deschildre, Antoine Brouard, Jacques Tazi, Abdellatif Meckenstock, Roderich Didier, Morgane Haroche, Julien Clement, Annick Bernaudin, Jean-François Nunes, Hilario Valeyre, Dominique Nathan, Nadia |
author_facet | Chauveau, Simon Jeny, Florence Montagne, Marie-Emeline Abou Taam, Rola Houdouin, Véronique Meinzer, Ulrich Delacourt, Christophe Epaud, Ralph Cohen Aubart, Fleur Chapelon-Abric, Catherine Israël-Biet, Dominique Juvin, Karine Dossier, Antoine Bodaghi, Bahram Prévot, Grégoire Naccache, Jean-Marc Mattioni, Sarah Deschildre, Antoine Brouard, Jacques Tazi, Abdellatif Meckenstock, Roderich Didier, Morgane Haroche, Julien Clement, Annick Bernaudin, Jean-François Nunes, Hilario Valeyre, Dominique Nathan, Nadia |
author_sort | Chauveau, Simon |
collection | PubMed |
description | (1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood. |
format | Online Article Text |
id | pubmed-7408766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74087662020-08-13 Child–Adult Transition in Sarcoidosis: A Series of 52 Patients Chauveau, Simon Jeny, Florence Montagne, Marie-Emeline Abou Taam, Rola Houdouin, Véronique Meinzer, Ulrich Delacourt, Christophe Epaud, Ralph Cohen Aubart, Fleur Chapelon-Abric, Catherine Israël-Biet, Dominique Juvin, Karine Dossier, Antoine Bodaghi, Bahram Prévot, Grégoire Naccache, Jean-Marc Mattioni, Sarah Deschildre, Antoine Brouard, Jacques Tazi, Abdellatif Meckenstock, Roderich Didier, Morgane Haroche, Julien Clement, Annick Bernaudin, Jean-François Nunes, Hilario Valeyre, Dominique Nathan, Nadia J Clin Med Article (1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood. MDPI 2020-07-03 /pmc/articles/PMC7408766/ /pubmed/32635292 http://dx.doi.org/10.3390/jcm9072097 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chauveau, Simon Jeny, Florence Montagne, Marie-Emeline Abou Taam, Rola Houdouin, Véronique Meinzer, Ulrich Delacourt, Christophe Epaud, Ralph Cohen Aubart, Fleur Chapelon-Abric, Catherine Israël-Biet, Dominique Juvin, Karine Dossier, Antoine Bodaghi, Bahram Prévot, Grégoire Naccache, Jean-Marc Mattioni, Sarah Deschildre, Antoine Brouard, Jacques Tazi, Abdellatif Meckenstock, Roderich Didier, Morgane Haroche, Julien Clement, Annick Bernaudin, Jean-François Nunes, Hilario Valeyre, Dominique Nathan, Nadia Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title | Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title_full | Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title_fullStr | Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title_full_unstemmed | Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title_short | Child–Adult Transition in Sarcoidosis: A Series of 52 Patients |
title_sort | child–adult transition in sarcoidosis: a series of 52 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408766/ https://www.ncbi.nlm.nih.gov/pubmed/32635292 http://dx.doi.org/10.3390/jcm9072097 |
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