Cargando…
Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide, affecting over 700,000 people per year. The treatment effect in advanced HCC is still disappointing and prognosis of advanced HCC remains poor. Hence, to find more effective therapeutic targets to improve the treat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408781/ https://www.ncbi.nlm.nih.gov/pubmed/32650537 http://dx.doi.org/10.3390/cancers12071843 |
_version_ | 1783567911491731456 |
---|---|
author | Chu, Pei-Yi Tung, Shiao-Lin Tsai, Kuo-Wang Shen, Fang-Ping Chan, Shih-Hsuan |
author_facet | Chu, Pei-Yi Tung, Shiao-Lin Tsai, Kuo-Wang Shen, Fang-Ping Chan, Shih-Hsuan |
author_sort | Chu, Pei-Yi |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide, affecting over 700,000 people per year. The treatment effect in advanced HCC is still disappointing and prognosis of advanced HCC remains poor. Hence, to find more effective therapeutic targets to improve the treatment outcome of HCC is of urgent need. In this study, we reported the novel oncogenic function of SAAL1 (serum amyloid A-like 1) in HCC, which previously is considered as an inflammation-related gene. We found that SAAL1 was significantly upregulated in HCC tumor tissues when compared to the adjacent normal tissues and high expression of SAAL1 correlated with shorter overall survival in The Cancer Genome Atlas (TCGA) HCC database. Functionally, we showed that the depletion of SAAL1 significantly reduced cell proliferation, 3D colony formation, and migration/invasion abilities of HCC cancer cells. Furthermore, suppression of SAAL1 impaired the HGF/Met-driven Akt/mTOR phosphorylation cascade and increased the chemosensitivity of HCC cells to sorafenib and foretinib treatment. Our data indicated that SAAL1 plays an important role in HCC via mediating oncogenic HGF/Met-driven Akt/mTOR signaling and could serve as an independent prognostic marker, as well as a promising therapeutic target for HCC patients. |
format | Online Article Text |
id | pubmed-7408781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74087812020-08-13 Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma Chu, Pei-Yi Tung, Shiao-Lin Tsai, Kuo-Wang Shen, Fang-Ping Chan, Shih-Hsuan Cancers (Basel) Article Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide, affecting over 700,000 people per year. The treatment effect in advanced HCC is still disappointing and prognosis of advanced HCC remains poor. Hence, to find more effective therapeutic targets to improve the treatment outcome of HCC is of urgent need. In this study, we reported the novel oncogenic function of SAAL1 (serum amyloid A-like 1) in HCC, which previously is considered as an inflammation-related gene. We found that SAAL1 was significantly upregulated in HCC tumor tissues when compared to the adjacent normal tissues and high expression of SAAL1 correlated with shorter overall survival in The Cancer Genome Atlas (TCGA) HCC database. Functionally, we showed that the depletion of SAAL1 significantly reduced cell proliferation, 3D colony formation, and migration/invasion abilities of HCC cancer cells. Furthermore, suppression of SAAL1 impaired the HGF/Met-driven Akt/mTOR phosphorylation cascade and increased the chemosensitivity of HCC cells to sorafenib and foretinib treatment. Our data indicated that SAAL1 plays an important role in HCC via mediating oncogenic HGF/Met-driven Akt/mTOR signaling and could serve as an independent prognostic marker, as well as a promising therapeutic target for HCC patients. MDPI 2020-07-08 /pmc/articles/PMC7408781/ /pubmed/32650537 http://dx.doi.org/10.3390/cancers12071843 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chu, Pei-Yi Tung, Shiao-Lin Tsai, Kuo-Wang Shen, Fang-Ping Chan, Shih-Hsuan Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title | Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title_full | Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title_fullStr | Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title_full_unstemmed | Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title_short | Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma |
title_sort | identification of the novel oncogenic role of saal1 and its therapeutic potential in hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408781/ https://www.ncbi.nlm.nih.gov/pubmed/32650537 http://dx.doi.org/10.3390/cancers12071843 |
work_keys_str_mv | AT chupeiyi identificationofthenoveloncogenicroleofsaal1anditstherapeuticpotentialinhepatocellularcarcinoma AT tungshiaolin identificationofthenoveloncogenicroleofsaal1anditstherapeuticpotentialinhepatocellularcarcinoma AT tsaikuowang identificationofthenoveloncogenicroleofsaal1anditstherapeuticpotentialinhepatocellularcarcinoma AT shenfangping identificationofthenoveloncogenicroleofsaal1anditstherapeuticpotentialinhepatocellularcarcinoma AT chanshihhsuan identificationofthenoveloncogenicroleofsaal1anditstherapeuticpotentialinhepatocellularcarcinoma |