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Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408797/ https://www.ncbi.nlm.nih.gov/pubmed/32635529 http://dx.doi.org/10.3390/jcm9072108 |
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author | Ávila-Gómez, Paulo Hervella, Pablo Da Silva-Candal, Andrés Pérez-Mato, María Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Castillo, José Sobrino, Tomás Iglesias-Rey, Ramón Campos, Francisco |
author_facet | Ávila-Gómez, Paulo Hervella, Pablo Da Silva-Candal, Andrés Pérez-Mato, María Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Castillo, José Sobrino, Tomás Iglesias-Rey, Ramón Campos, Francisco |
author_sort | Ávila-Gómez, Paulo |
collection | PubMed |
description | Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis. |
format | Online Article Text |
id | pubmed-7408797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74087972020-08-13 Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers Ávila-Gómez, Paulo Hervella, Pablo Da Silva-Candal, Andrés Pérez-Mato, María Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Castillo, José Sobrino, Tomás Iglesias-Rey, Ramón Campos, Francisco J Clin Med Article Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis. MDPI 2020-07-04 /pmc/articles/PMC7408797/ /pubmed/32635529 http://dx.doi.org/10.3390/jcm9072108 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ávila-Gómez, Paulo Hervella, Pablo Da Silva-Candal, Andrés Pérez-Mato, María Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Castillo, José Sobrino, Tomás Iglesias-Rey, Ramón Campos, Francisco Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title | Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title_full | Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title_fullStr | Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title_full_unstemmed | Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title_short | Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers |
title_sort | temperature-induced changes in reperfused stroke: inflammatory and thrombolytic biomarkers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408797/ https://www.ncbi.nlm.nih.gov/pubmed/32635529 http://dx.doi.org/10.3390/jcm9072108 |
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