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Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers

Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of...

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Autores principales: Ávila-Gómez, Paulo, Hervella, Pablo, Da Silva-Candal, Andrés, Pérez-Mato, María, Rodríguez-Yáñez, Manuel, López-Dequidt, Iria, Pumar, José M., Castillo, José, Sobrino, Tomás, Iglesias-Rey, Ramón, Campos, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408797/
https://www.ncbi.nlm.nih.gov/pubmed/32635529
http://dx.doi.org/10.3390/jcm9072108
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author Ávila-Gómez, Paulo
Hervella, Pablo
Da Silva-Candal, Andrés
Pérez-Mato, María
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Castillo, José
Sobrino, Tomás
Iglesias-Rey, Ramón
Campos, Francisco
author_facet Ávila-Gómez, Paulo
Hervella, Pablo
Da Silva-Candal, Andrés
Pérez-Mato, María
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Castillo, José
Sobrino, Tomás
Iglesias-Rey, Ramón
Campos, Francisco
author_sort Ávila-Gómez, Paulo
collection PubMed
description Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis.
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spelling pubmed-74087972020-08-13 Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers Ávila-Gómez, Paulo Hervella, Pablo Da Silva-Candal, Andrés Pérez-Mato, María Rodríguez-Yáñez, Manuel López-Dequidt, Iria Pumar, José M. Castillo, José Sobrino, Tomás Iglesias-Rey, Ramón Campos, Francisco J Clin Med Article Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis. MDPI 2020-07-04 /pmc/articles/PMC7408797/ /pubmed/32635529 http://dx.doi.org/10.3390/jcm9072108 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ávila-Gómez, Paulo
Hervella, Pablo
Da Silva-Candal, Andrés
Pérez-Mato, María
Rodríguez-Yáñez, Manuel
López-Dequidt, Iria
Pumar, José M.
Castillo, José
Sobrino, Tomás
Iglesias-Rey, Ramón
Campos, Francisco
Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title_full Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title_fullStr Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title_full_unstemmed Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title_short Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
title_sort temperature-induced changes in reperfused stroke: inflammatory and thrombolytic biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408797/
https://www.ncbi.nlm.nih.gov/pubmed/32635529
http://dx.doi.org/10.3390/jcm9072108
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