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Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population

This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed th...

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Autores principales: Vilanova, Maria Belén, Franch-Nadal, Josep, Falguera, Mireia, Marsal, Josep Ramon, Canivell, Sílvia, Rubinat, Esther, Miró, Neus, Molló, Àngels, Mata-Cases, Manel, Gratacòs, Mònica, Castelblanco, Esmeralda, Mauricio, Dídac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408832/
https://www.ncbi.nlm.nih.gov/pubmed/32645918
http://dx.doi.org/10.3390/jcm9072139
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author Vilanova, Maria Belén
Franch-Nadal, Josep
Falguera, Mireia
Marsal, Josep Ramon
Canivell, Sílvia
Rubinat, Esther
Miró, Neus
Molló, Àngels
Mata-Cases, Manel
Gratacòs, Mònica
Castelblanco, Esmeralda
Mauricio, Dídac
author_facet Vilanova, Maria Belén
Franch-Nadal, Josep
Falguera, Mireia
Marsal, Josep Ramon
Canivell, Sílvia
Rubinat, Esther
Miró, Neus
Molló, Àngels
Mata-Cases, Manel
Gratacòs, Mònica
Castelblanco, Esmeralda
Mauricio, Dídac
author_sort Vilanova, Maria Belén
collection PubMed
description This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm, p < 0.001; and 37.9% vs. 19.6%; p < 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05–2.57; p = 0.03 and OR = 1.01; 95% CI = 1.00–1.02; p = 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08–2.89; p = 0.023 and OR = 1.20; 95% CI = 1.05–1.38; p = 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear.
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spelling pubmed-74088322020-08-13 Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population Vilanova, Maria Belén Franch-Nadal, Josep Falguera, Mireia Marsal, Josep Ramon Canivell, Sílvia Rubinat, Esther Miró, Neus Molló, Àngels Mata-Cases, Manel Gratacòs, Mònica Castelblanco, Esmeralda Mauricio, Dídac J Clin Med Article This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm, p < 0.001; and 37.9% vs. 19.6%; p < 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05–2.57; p = 0.03 and OR = 1.01; 95% CI = 1.00–1.02; p = 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08–2.89; p = 0.023 and OR = 1.20; 95% CI = 1.05–1.38; p = 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear. MDPI 2020-07-07 /pmc/articles/PMC7408832/ /pubmed/32645918 http://dx.doi.org/10.3390/jcm9072139 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vilanova, Maria Belén
Franch-Nadal, Josep
Falguera, Mireia
Marsal, Josep Ramon
Canivell, Sílvia
Rubinat, Esther
Miró, Neus
Molló, Àngels
Mata-Cases, Manel
Gratacòs, Mònica
Castelblanco, Esmeralda
Mauricio, Dídac
Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title_full Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title_fullStr Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title_full_unstemmed Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title_short Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
title_sort prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408832/
https://www.ncbi.nlm.nih.gov/pubmed/32645918
http://dx.doi.org/10.3390/jcm9072139
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