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Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed th...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408832/ https://www.ncbi.nlm.nih.gov/pubmed/32645918 http://dx.doi.org/10.3390/jcm9072139 |
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author | Vilanova, Maria Belén Franch-Nadal, Josep Falguera, Mireia Marsal, Josep Ramon Canivell, Sílvia Rubinat, Esther Miró, Neus Molló, Àngels Mata-Cases, Manel Gratacòs, Mònica Castelblanco, Esmeralda Mauricio, Dídac |
author_facet | Vilanova, Maria Belén Franch-Nadal, Josep Falguera, Mireia Marsal, Josep Ramon Canivell, Sílvia Rubinat, Esther Miró, Neus Molló, Àngels Mata-Cases, Manel Gratacòs, Mònica Castelblanco, Esmeralda Mauricio, Dídac |
author_sort | Vilanova, Maria Belén |
collection | PubMed |
description | This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm, p < 0.001; and 37.9% vs. 19.6%; p < 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05–2.57; p = 0.03 and OR = 1.01; 95% CI = 1.00–1.02; p = 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08–2.89; p = 0.023 and OR = 1.20; 95% CI = 1.05–1.38; p = 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear. |
format | Online Article Text |
id | pubmed-7408832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74088322020-08-13 Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population Vilanova, Maria Belén Franch-Nadal, Josep Falguera, Mireia Marsal, Josep Ramon Canivell, Sílvia Rubinat, Esther Miró, Neus Molló, Àngels Mata-Cases, Manel Gratacòs, Mònica Castelblanco, Esmeralda Mauricio, Dídac J Clin Med Article This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm, p < 0.001; and 37.9% vs. 19.6%; p < 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05–2.57; p = 0.03 and OR = 1.01; 95% CI = 1.00–1.02; p = 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08–2.89; p = 0.023 and OR = 1.20; 95% CI = 1.05–1.38; p = 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear. MDPI 2020-07-07 /pmc/articles/PMC7408832/ /pubmed/32645918 http://dx.doi.org/10.3390/jcm9072139 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vilanova, Maria Belén Franch-Nadal, Josep Falguera, Mireia Marsal, Josep Ramon Canivell, Sílvia Rubinat, Esther Miró, Neus Molló, Àngels Mata-Cases, Manel Gratacòs, Mònica Castelblanco, Esmeralda Mauricio, Dídac Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title | Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title_full | Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title_fullStr | Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title_full_unstemmed | Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title_short | Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population |
title_sort | prediabetes is independently associated with subclinical carotid atherosclerosis: an observational study in a non-urban mediterranean population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408832/ https://www.ncbi.nlm.nih.gov/pubmed/32645918 http://dx.doi.org/10.3390/jcm9072139 |
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