Cargando…

High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study

Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will increase awareness to prevent further loss of muscle mass. We utilized data from a...

Descripción completa

Detalles Bibliográficos
Autores principales: Stassen, Robert C., Reisinger, Kostan W., Al-Ali, Moaath, Poeze, Martijn, Ten Bosch, Jan A., Blokhuis, Taco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408833/
https://www.ncbi.nlm.nih.gov/pubmed/32610680
http://dx.doi.org/10.3390/jcm9072046
_version_ 1783567923728613376
author Stassen, Robert C.
Reisinger, Kostan W.
Al-Ali, Moaath
Poeze, Martijn
Ten Bosch, Jan A.
Blokhuis, Taco J.
author_facet Stassen, Robert C.
Reisinger, Kostan W.
Al-Ali, Moaath
Poeze, Martijn
Ten Bosch, Jan A.
Blokhuis, Taco J.
author_sort Stassen, Robert C.
collection PubMed
description Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will increase awareness to prevent further loss of muscle mass. We utilized data from a regional prospective trauma registry of all polytrauma patients presented between 2015 and 2019 at a single level-I trauma center. Subjects were screened for availability of computed tomography (CT)-abdomen and height in order to calculate skeletal mass index, which was used to estimate sarcopenia. Additional parameters regarding clinical outcome were assessed. Univariate analysis was performed to identify parameters related adverse outcome and, if identified, entered in a multivariate regression analysis. Prevalence of sarcopenia was 33.5% in the total population but was even higher in older age groups (range 60–79 years), reaching 82 % in patients over 80 years old. Sarcopenia was related to 30-day or in-hospital mortality (p = 0.032), as well as age (p < 0.0001), injury severity score (p = 0.026), and Charlson comorbidity index (p = 0.001). Log rank analysis identified sarcopenia as an independent predictor of 30-day mortality (p = 0.032). In conclusion, we observed a high prevalence of sarcopenia among polytrauma patients, further increasing in older patients. In addition, sarcopenia was identified as a predictor for 30-day mortality, underlining the clinical significance of identification of low muscle mass on a CT scan that is already routinely obtained in most trauma patients.
format Online
Article
Text
id pubmed-7408833
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74088332020-08-13 High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study Stassen, Robert C. Reisinger, Kostan W. Al-Ali, Moaath Poeze, Martijn Ten Bosch, Jan A. Blokhuis, Taco J. J Clin Med Article Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will increase awareness to prevent further loss of muscle mass. We utilized data from a regional prospective trauma registry of all polytrauma patients presented between 2015 and 2019 at a single level-I trauma center. Subjects were screened for availability of computed tomography (CT)-abdomen and height in order to calculate skeletal mass index, which was used to estimate sarcopenia. Additional parameters regarding clinical outcome were assessed. Univariate analysis was performed to identify parameters related adverse outcome and, if identified, entered in a multivariate regression analysis. Prevalence of sarcopenia was 33.5% in the total population but was even higher in older age groups (range 60–79 years), reaching 82 % in patients over 80 years old. Sarcopenia was related to 30-day or in-hospital mortality (p = 0.032), as well as age (p < 0.0001), injury severity score (p = 0.026), and Charlson comorbidity index (p = 0.001). Log rank analysis identified sarcopenia as an independent predictor of 30-day mortality (p = 0.032). In conclusion, we observed a high prevalence of sarcopenia among polytrauma patients, further increasing in older patients. In addition, sarcopenia was identified as a predictor for 30-day mortality, underlining the clinical significance of identification of low muscle mass on a CT scan that is already routinely obtained in most trauma patients. MDPI 2020-06-29 /pmc/articles/PMC7408833/ /pubmed/32610680 http://dx.doi.org/10.3390/jcm9072046 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stassen, Robert C.
Reisinger, Kostan W.
Al-Ali, Moaath
Poeze, Martijn
Ten Bosch, Jan A.
Blokhuis, Taco J.
High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title_full High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title_fullStr High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title_full_unstemmed High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title_short High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study
title_sort high prevalence of sarcopenia in older trauma patients: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408833/
https://www.ncbi.nlm.nih.gov/pubmed/32610680
http://dx.doi.org/10.3390/jcm9072046
work_keys_str_mv AT stassenrobertc highprevalenceofsarcopeniainoldertraumapatientsapilotstudy
AT reisingerkostanw highprevalenceofsarcopeniainoldertraumapatientsapilotstudy
AT alalimoaath highprevalenceofsarcopeniainoldertraumapatientsapilotstudy
AT poezemartijn highprevalenceofsarcopeniainoldertraumapatientsapilotstudy
AT tenboschjana highprevalenceofsarcopeniainoldertraumapatientsapilotstudy
AT blokhuistacoj highprevalenceofsarcopeniainoldertraumapatientsapilotstudy