Cargando…
Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a pre...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408845/ https://www.ncbi.nlm.nih.gov/pubmed/32679845 http://dx.doi.org/10.3390/jcm9072247 |
_version_ | 1783567926509436928 |
---|---|
author | Gárate-Escamilla, Anna Karen Garza-Padilla, Edelmiro Carvajal Rivera, Agustín Salas-Castro, Celina Andrès, Emmanuel Hajjam El Hassani, Amir |
author_facet | Gárate-Escamilla, Anna Karen Garza-Padilla, Edelmiro Carvajal Rivera, Agustín Salas-Castro, Celina Andrès, Emmanuel Hajjam El Hassani, Amir |
author_sort | Gárate-Escamilla, Anna Karen |
collection | PubMed |
description | Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a prenatal control consultation between January 2016 and December 2017 at the Women’s Institute in Monterrey, Mexico. The studied sample had homogeneous demographic characteristics in terms of age, weight, height, BMI (body mass index) and number of pregnancies. The presence of at least one of the risk factors for thyroid disease was observed in 39.2% of the sample. Two and three clusters were identified, in which patients varied considerably among risk factors, symptoms and pregnancy complications. Compared to Cluster 0, one or more symptoms or signs of hypothyroidism occurred, while Cluster 1 was characterized by healthier patients. When three clusters were used, Cluster 2 had a higher TSH (thyroid stimulating hormone) value and pregnancy complications. There were no significant differences in perinatal variables. In addition, high TSH levels in first trimester pregnancy are characterized by pregnancy complications and decreased newborn weight. Our findings underline the high degree of disease heterogeneity with existing pregnant hypothyroid patients and the need to improve the phenotyping of the syndrome in the Mexican population. |
format | Online Article Text |
id | pubmed-7408845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74088452020-08-13 Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women Gárate-Escamilla, Anna Karen Garza-Padilla, Edelmiro Carvajal Rivera, Agustín Salas-Castro, Celina Andrès, Emmanuel Hajjam El Hassani, Amir J Clin Med Article Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a prenatal control consultation between January 2016 and December 2017 at the Women’s Institute in Monterrey, Mexico. The studied sample had homogeneous demographic characteristics in terms of age, weight, height, BMI (body mass index) and number of pregnancies. The presence of at least one of the risk factors for thyroid disease was observed in 39.2% of the sample. Two and three clusters were identified, in which patients varied considerably among risk factors, symptoms and pregnancy complications. Compared to Cluster 0, one or more symptoms or signs of hypothyroidism occurred, while Cluster 1 was characterized by healthier patients. When three clusters were used, Cluster 2 had a higher TSH (thyroid stimulating hormone) value and pregnancy complications. There were no significant differences in perinatal variables. In addition, high TSH levels in first trimester pregnancy are characterized by pregnancy complications and decreased newborn weight. Our findings underline the high degree of disease heterogeneity with existing pregnant hypothyroid patients and the need to improve the phenotyping of the syndrome in the Mexican population. MDPI 2020-07-15 /pmc/articles/PMC7408845/ /pubmed/32679845 http://dx.doi.org/10.3390/jcm9072247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gárate-Escamilla, Anna Karen Garza-Padilla, Edelmiro Carvajal Rivera, Agustín Salas-Castro, Celina Andrès, Emmanuel Hajjam El Hassani, Amir Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title | Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title_full | Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title_fullStr | Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title_full_unstemmed | Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title_short | Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women |
title_sort | cluster analysis: a new approach for identification of underlying risk factors and demographic features of first trimester pregnancy women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408845/ https://www.ncbi.nlm.nih.gov/pubmed/32679845 http://dx.doi.org/10.3390/jcm9072247 |
work_keys_str_mv | AT garateescamillaannakaren clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen AT garzapadillaedelmiro clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen AT carvajalriveraagustin clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen AT salascastrocelina clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen AT andresemmanuel clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen AT hajjamelhassaniamir clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen |