Cargando…

Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women

Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Gárate-Escamilla, Anna Karen, Garza-Padilla, Edelmiro, Carvajal Rivera, Agustín, Salas-Castro, Celina, Andrès, Emmanuel, Hajjam El Hassani, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408845/
https://www.ncbi.nlm.nih.gov/pubmed/32679845
http://dx.doi.org/10.3390/jcm9072247
_version_ 1783567926509436928
author Gárate-Escamilla, Anna Karen
Garza-Padilla, Edelmiro
Carvajal Rivera, Agustín
Salas-Castro, Celina
Andrès, Emmanuel
Hajjam El Hassani, Amir
author_facet Gárate-Escamilla, Anna Karen
Garza-Padilla, Edelmiro
Carvajal Rivera, Agustín
Salas-Castro, Celina
Andrès, Emmanuel
Hajjam El Hassani, Amir
author_sort Gárate-Escamilla, Anna Karen
collection PubMed
description Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a prenatal control consultation between January 2016 and December 2017 at the Women’s Institute in Monterrey, Mexico. The studied sample had homogeneous demographic characteristics in terms of age, weight, height, BMI (body mass index) and number of pregnancies. The presence of at least one of the risk factors for thyroid disease was observed in 39.2% of the sample. Two and three clusters were identified, in which patients varied considerably among risk factors, symptoms and pregnancy complications. Compared to Cluster 0, one or more symptoms or signs of hypothyroidism occurred, while Cluster 1 was characterized by healthier patients. When three clusters were used, Cluster 2 had a higher TSH (thyroid stimulating hormone) value and pregnancy complications. There were no significant differences in perinatal variables. In addition, high TSH levels in first trimester pregnancy are characterized by pregnancy complications and decreased newborn weight. Our findings underline the high degree of disease heterogeneity with existing pregnant hypothyroid patients and the need to improve the phenotyping of the syndrome in the Mexican population.
format Online
Article
Text
id pubmed-7408845
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74088452020-08-13 Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women Gárate-Escamilla, Anna Karen Garza-Padilla, Edelmiro Carvajal Rivera, Agustín Salas-Castro, Celina Andrès, Emmanuel Hajjam El Hassani, Amir J Clin Med Article Thyroid pathology is reported internationally in 5–10% of all pregnancies. The overall aim of this research was to determine the prevalence of hypothyroidism and risk factors during the first trimester screening in a Mexican patients sample. We included the records of 306 patients who attended a prenatal control consultation between January 2016 and December 2017 at the Women’s Institute in Monterrey, Mexico. The studied sample had homogeneous demographic characteristics in terms of age, weight, height, BMI (body mass index) and number of pregnancies. The presence of at least one of the risk factors for thyroid disease was observed in 39.2% of the sample. Two and three clusters were identified, in which patients varied considerably among risk factors, symptoms and pregnancy complications. Compared to Cluster 0, one or more symptoms or signs of hypothyroidism occurred, while Cluster 1 was characterized by healthier patients. When three clusters were used, Cluster 2 had a higher TSH (thyroid stimulating hormone) value and pregnancy complications. There were no significant differences in perinatal variables. In addition, high TSH levels in first trimester pregnancy are characterized by pregnancy complications and decreased newborn weight. Our findings underline the high degree of disease heterogeneity with existing pregnant hypothyroid patients and the need to improve the phenotyping of the syndrome in the Mexican population. MDPI 2020-07-15 /pmc/articles/PMC7408845/ /pubmed/32679845 http://dx.doi.org/10.3390/jcm9072247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gárate-Escamilla, Anna Karen
Garza-Padilla, Edelmiro
Carvajal Rivera, Agustín
Salas-Castro, Celina
Andrès, Emmanuel
Hajjam El Hassani, Amir
Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title_full Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title_fullStr Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title_full_unstemmed Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title_short Cluster Analysis: A New Approach for Identification of Underlying Risk Factors and Demographic Features of First Trimester Pregnancy Women
title_sort cluster analysis: a new approach for identification of underlying risk factors and demographic features of first trimester pregnancy women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408845/
https://www.ncbi.nlm.nih.gov/pubmed/32679845
http://dx.doi.org/10.3390/jcm9072247
work_keys_str_mv AT garateescamillaannakaren clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen
AT garzapadillaedelmiro clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen
AT carvajalriveraagustin clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen
AT salascastrocelina clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen
AT andresemmanuel clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen
AT hajjamelhassaniamir clusteranalysisanewapproachforidentificationofunderlyingriskfactorsanddemographicfeaturesoffirsttrimesterpregnancywomen