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Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation

In twin gestation, the relationship between pregnancy associated plasma protein (PAPP-A) and perinatal outcome is unclear. The aim of the study was to determine if low and high concentrations of PAPP-A in the first trimester are related to perinatal outcome in twins. A retrospective study was conduc...

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Autores principales: Saletra-Bielińska, Aleksandra, Kosińska-Kaczyńska, Katarzyna, Szymusik, Iwona, Kaczyński, Bartosz, Brawura-Biskupski-Samaha, Robert, Kozłowski, Szymon, Jarmużek, Patrycja, Walasik, Izabela, Wielgoś, Mirosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408854/
https://www.ncbi.nlm.nih.gov/pubmed/32635314
http://dx.doi.org/10.3390/jcm9072099
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author Saletra-Bielińska, Aleksandra
Kosińska-Kaczyńska, Katarzyna
Szymusik, Iwona
Kaczyński, Bartosz
Brawura-Biskupski-Samaha, Robert
Kozłowski, Szymon
Jarmużek, Patrycja
Walasik, Izabela
Wielgoś, Mirosław
author_facet Saletra-Bielińska, Aleksandra
Kosińska-Kaczyńska, Katarzyna
Szymusik, Iwona
Kaczyński, Bartosz
Brawura-Biskupski-Samaha, Robert
Kozłowski, Szymon
Jarmużek, Patrycja
Walasik, Izabela
Wielgoś, Mirosław
author_sort Saletra-Bielińska, Aleksandra
collection PubMed
description In twin gestation, the relationship between pregnancy associated plasma protein (PAPP-A) and perinatal outcome is unclear. The aim of the study was to determine if low and high concentrations of PAPP-A in the first trimester are related to perinatal outcome in twins. A retrospective study was conducted. Medical data of women in twin pregnancies who delivered between 2013 and 2018 were analyzed. PAPP-A concentrations were measured between 10 + 0 and 13 + 6 weeks. The associations between low (<10th percentile) and high (>90th percentile) values of PAPP-A and pregnancy complications were analyzed. A total of 304 patients were included. PAPP-A <10th percentile was associated with a high risk of preterm delivery (OR 6.14; 95% CI 2.1–18), delivery <34 weeks (OR 2.39; 95% CI 1.1–5.1) or <32 weeks (OR3.06; 95% CI 1.4–6.8). Significant relations between PAPP-A >90th percentile and delivery <34 weeks (OR4.09; 95% CI 1.8–9.1) or <32 weeks (OR 2.83; 95% CI 1.2–6.6) were found. PAPP-A >90th percentile was related to high risk of intrauterine fetal demise (OR 10; 95% CI 2.4–42.5). Both low and high PAPP-A concentrations seem to be related to pregnancy outcome. Further research is needed to investigate evaluation of risk of pregnancy complications according to PAPP-A concentrations as a continuous variable.
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spelling pubmed-74088542020-08-13 Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation Saletra-Bielińska, Aleksandra Kosińska-Kaczyńska, Katarzyna Szymusik, Iwona Kaczyński, Bartosz Brawura-Biskupski-Samaha, Robert Kozłowski, Szymon Jarmużek, Patrycja Walasik, Izabela Wielgoś, Mirosław J Clin Med Article In twin gestation, the relationship between pregnancy associated plasma protein (PAPP-A) and perinatal outcome is unclear. The aim of the study was to determine if low and high concentrations of PAPP-A in the first trimester are related to perinatal outcome in twins. A retrospective study was conducted. Medical data of women in twin pregnancies who delivered between 2013 and 2018 were analyzed. PAPP-A concentrations were measured between 10 + 0 and 13 + 6 weeks. The associations between low (<10th percentile) and high (>90th percentile) values of PAPP-A and pregnancy complications were analyzed. A total of 304 patients were included. PAPP-A <10th percentile was associated with a high risk of preterm delivery (OR 6.14; 95% CI 2.1–18), delivery <34 weeks (OR 2.39; 95% CI 1.1–5.1) or <32 weeks (OR3.06; 95% CI 1.4–6.8). Significant relations between PAPP-A >90th percentile and delivery <34 weeks (OR4.09; 95% CI 1.8–9.1) or <32 weeks (OR 2.83; 95% CI 1.2–6.6) were found. PAPP-A >90th percentile was related to high risk of intrauterine fetal demise (OR 10; 95% CI 2.4–42.5). Both low and high PAPP-A concentrations seem to be related to pregnancy outcome. Further research is needed to investigate evaluation of risk of pregnancy complications according to PAPP-A concentrations as a continuous variable. MDPI 2020-07-03 /pmc/articles/PMC7408854/ /pubmed/32635314 http://dx.doi.org/10.3390/jcm9072099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saletra-Bielińska, Aleksandra
Kosińska-Kaczyńska, Katarzyna
Szymusik, Iwona
Kaczyński, Bartosz
Brawura-Biskupski-Samaha, Robert
Kozłowski, Szymon
Jarmużek, Patrycja
Walasik, Izabela
Wielgoś, Mirosław
Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title_full Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title_fullStr Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title_full_unstemmed Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title_short Both Low and High PAPP-A Concentrations in the First Trimester of Pregnancy Are Associated with Increased Risk of Delivery before 32 Weeks in Twin Gestation
title_sort both low and high papp-a concentrations in the first trimester of pregnancy are associated with increased risk of delivery before 32 weeks in twin gestation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408854/
https://www.ncbi.nlm.nih.gov/pubmed/32635314
http://dx.doi.org/10.3390/jcm9072099
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