Drug Tissue Distribution of TUDCA From a Biodegradable Suprachoroidal Implant versus Intravitreal or Systemic Delivery in the Pig Model

PURPOSE: To determine local ocular tissue levels of the bile acid, tauroursodeoxycholic acid (TUDCA), in the pig model using oral, intravenous (IV), intravitreal injection (IVitI) and low- and high-dose suprachoroidal, sustained-release implants (SCI-L or SCI-H). METHODS: Forty-six pigs (92 globes)...

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Detalles Bibliográficos
Autores principales: Olsen, Timothy W., Dyer, Roy B., Mano, Fukutaro, Boatright, Jeffrey H., Chrenek, Micah A., Paley, Daniel, Wabner, Kathy, Schmit, Jenn, Chae, Ju Byung, Sellers, Jana T., Singh, Ravinder J., Wiedmann, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408862/
https://www.ncbi.nlm.nih.gov/pubmed/32821508
http://dx.doi.org/10.1167/tvst.9.6.11

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