Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3′ Splice-Site Selection

U2AF65 (U2AF2) and PUF60 (PUF60) are splicing factors important for recruitment of the U2 small nuclear ribonucleoprotein to lariat branch points and selection of 3′ splice sites (3′ss). Both proteins preferentially bind uridine-rich sequences upstream of 3′ss via their RNA recognition motifs (RRMs)...

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Detalles Bibliográficos
Autores principales: Kralovicova, Jana, Borovska, Ivana, Kubickova, Monika, Lukavsky, Peter J., Vorechovsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408900/
https://www.ncbi.nlm.nih.gov/pubmed/32664474
http://dx.doi.org/10.3390/cancers12071865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408900/
https://www.ncbi.nlm.nih.gov/pubmed/32664474
http://dx.doi.org/10.3390/cancers12071865

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