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ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications

The erythroblastic leukemia viral oncogene homolog (ErBb) family consists of the receptor tyrosine kinases (RTK) epidermal growth factor receptor (EGFR; also called ERBB1), ERBB2, ERBB3, and ERBB4. This family is closely associated with the progression of cholangiocarcinoma (CC) through the regulati...

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Detalles Bibliográficos
Autor principal: Jin, Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408920/
https://www.ncbi.nlm.nih.gov/pubmed/32708604
http://dx.doi.org/10.3390/jcm9072255
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author Jin, Wook
author_facet Jin, Wook
author_sort Jin, Wook
collection PubMed
description The erythroblastic leukemia viral oncogene homolog (ErBb) family consists of the receptor tyrosine kinases (RTK) epidermal growth factor receptor (EGFR; also called ERBB1), ERBB2, ERBB3, and ERBB4. This family is closely associated with the progression of cholangiocarcinoma (CC) through the regulation of cellular networks, which are enhanced during tumorigenesis, metastasis, and chemoresistance. Additionally, the constitutive activation of cellular signaling by the overexpression and somatic mutation-mediated alterations conferred by the ErBb family on cholangiocarcinoma and other cancers enhances tumor aggressiveness and chemoresistance by contributing to the tumor microenvironment. This review summarizes the recent findings on the molecular functions of the ErBb family and their mutations during the progression of cholangiocarcinoma. It also discusses the developments and applications of various devising strategies for targeting the ErBb family through different inhibitors in various stages of clinical trials, which are essential for improving targeted clinical therapies.
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spelling pubmed-74089202020-08-13 ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications Jin, Wook J Clin Med Review The erythroblastic leukemia viral oncogene homolog (ErBb) family consists of the receptor tyrosine kinases (RTK) epidermal growth factor receptor (EGFR; also called ERBB1), ERBB2, ERBB3, and ERBB4. This family is closely associated with the progression of cholangiocarcinoma (CC) through the regulation of cellular networks, which are enhanced during tumorigenesis, metastasis, and chemoresistance. Additionally, the constitutive activation of cellular signaling by the overexpression and somatic mutation-mediated alterations conferred by the ErBb family on cholangiocarcinoma and other cancers enhances tumor aggressiveness and chemoresistance by contributing to the tumor microenvironment. This review summarizes the recent findings on the molecular functions of the ErBb family and their mutations during the progression of cholangiocarcinoma. It also discusses the developments and applications of various devising strategies for targeting the ErBb family through different inhibitors in various stages of clinical trials, which are essential for improving targeted clinical therapies. MDPI 2020-07-16 /pmc/articles/PMC7408920/ /pubmed/32708604 http://dx.doi.org/10.3390/jcm9072255 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jin, Wook
ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title_full ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title_fullStr ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title_full_unstemmed ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title_short ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications
title_sort erbb family proteins in cholangiocarcinoma and clinical implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408920/
https://www.ncbi.nlm.nih.gov/pubmed/32708604
http://dx.doi.org/10.3390/jcm9072255
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