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miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408929/ https://www.ncbi.nlm.nih.gov/pubmed/32605009 http://dx.doi.org/10.3390/cells9071566 |
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author | Godínez-Rubí, Marisol Ortuño-Sahagún, Daniel |
author_facet | Godínez-Rubí, Marisol Ortuño-Sahagún, Daniel |
author_sort | Godínez-Rubí, Marisol |
collection | PubMed |
description | MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of which affects physiological processes and contributes to a great diversity of diseases. In the present review, we focus on miR-615, a miRNA highly conserved across eutherian mammals. It is involved not only during embryogenesis in the regulation of growth and development, for instance during osteogenesis and angiogenesis, but also in the regulation of cell growth and the proliferation and migration of cells, acting as a tumor suppressor or tumor promoter. It therefore serves as a biomarker for several types of cancer, and recently has also been found to be involved in reparative processes and neural repair. In addition, we present the pleiad of functions in which miR-615 is involved, as well as their multiple target genes and the multiple regulatory molecules involved in its own expression. We do this by introducing in a comprehensible way the reported knowledge of their actions and interactions and proposing an integral view of its regulatory mechanisms. |
format | Online Article Text |
id | pubmed-7408929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74089292020-08-13 miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair Godínez-Rubí, Marisol Ortuño-Sahagún, Daniel Cells Review MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of which affects physiological processes and contributes to a great diversity of diseases. In the present review, we focus on miR-615, a miRNA highly conserved across eutherian mammals. It is involved not only during embryogenesis in the regulation of growth and development, for instance during osteogenesis and angiogenesis, but also in the regulation of cell growth and the proliferation and migration of cells, acting as a tumor suppressor or tumor promoter. It therefore serves as a biomarker for several types of cancer, and recently has also been found to be involved in reparative processes and neural repair. In addition, we present the pleiad of functions in which miR-615 is involved, as well as their multiple target genes and the multiple regulatory molecules involved in its own expression. We do this by introducing in a comprehensible way the reported knowledge of their actions and interactions and proposing an integral view of its regulatory mechanisms. MDPI 2020-06-27 /pmc/articles/PMC7408929/ /pubmed/32605009 http://dx.doi.org/10.3390/cells9071566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Godínez-Rubí, Marisol Ortuño-Sahagún, Daniel miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title | miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title_full | miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title_fullStr | miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title_full_unstemmed | miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title_short | miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair |
title_sort | mir-615 fine-tunes growth and development and has a role in cancer and in neural repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408929/ https://www.ncbi.nlm.nih.gov/pubmed/32605009 http://dx.doi.org/10.3390/cells9071566 |
work_keys_str_mv | AT godinezrubimarisol mir615finetunesgrowthanddevelopmentandhasaroleincancerandinneuralrepair AT ortunosahagundaniel mir615finetunesgrowthanddevelopmentandhasaroleincancerandinneuralrepair |