Cargando…

miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair

MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Godínez-Rubí, Marisol, Ortuño-Sahagún, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408929/
https://www.ncbi.nlm.nih.gov/pubmed/32605009
http://dx.doi.org/10.3390/cells9071566
_version_ 1783567946094739456
author Godínez-Rubí, Marisol
Ortuño-Sahagún, Daniel
author_facet Godínez-Rubí, Marisol
Ortuño-Sahagún, Daniel
author_sort Godínez-Rubí, Marisol
collection PubMed
description MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of which affects physiological processes and contributes to a great diversity of diseases. In the present review, we focus on miR-615, a miRNA highly conserved across eutherian mammals. It is involved not only during embryogenesis in the regulation of growth and development, for instance during osteogenesis and angiogenesis, but also in the regulation of cell growth and the proliferation and migration of cells, acting as a tumor suppressor or tumor promoter. It therefore serves as a biomarker for several types of cancer, and recently has also been found to be involved in reparative processes and neural repair. In addition, we present the pleiad of functions in which miR-615 is involved, as well as their multiple target genes and the multiple regulatory molecules involved in its own expression. We do this by introducing in a comprehensible way the reported knowledge of their actions and interactions and proposing an integral view of its regulatory mechanisms.
format Online
Article
Text
id pubmed-7408929
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74089292020-08-13 miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair Godínez-Rubí, Marisol Ortuño-Sahagún, Daniel Cells Review MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of which affects physiological processes and contributes to a great diversity of diseases. In the present review, we focus on miR-615, a miRNA highly conserved across eutherian mammals. It is involved not only during embryogenesis in the regulation of growth and development, for instance during osteogenesis and angiogenesis, but also in the regulation of cell growth and the proliferation and migration of cells, acting as a tumor suppressor or tumor promoter. It therefore serves as a biomarker for several types of cancer, and recently has also been found to be involved in reparative processes and neural repair. In addition, we present the pleiad of functions in which miR-615 is involved, as well as their multiple target genes and the multiple regulatory molecules involved in its own expression. We do this by introducing in a comprehensible way the reported knowledge of their actions and interactions and proposing an integral view of its regulatory mechanisms. MDPI 2020-06-27 /pmc/articles/PMC7408929/ /pubmed/32605009 http://dx.doi.org/10.3390/cells9071566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Godínez-Rubí, Marisol
Ortuño-Sahagún, Daniel
miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title_full miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title_fullStr miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title_full_unstemmed miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title_short miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair
title_sort mir-615 fine-tunes growth and development and has a role in cancer and in neural repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408929/
https://www.ncbi.nlm.nih.gov/pubmed/32605009
http://dx.doi.org/10.3390/cells9071566
work_keys_str_mv AT godinezrubimarisol mir615finetunesgrowthanddevelopmentandhasaroleincancerandinneuralrepair
AT ortunosahagundaniel mir615finetunesgrowthanddevelopmentandhasaroleincancerandinneuralrepair