Cargando…
Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A to...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408950/ https://www.ncbi.nlm.nih.gov/pubmed/32708872 http://dx.doi.org/10.3390/jcm9072268 |
_version_ | 1783567950975860736 |
---|---|
author | Ko, Jae-Hoon Joo, Eun-Jeong Park, Su-Jin Baek, Jin Yang Kim, Won Duk Jee, Jaehwan Kim, Chul Joong Jeong, Chul Kim, Yae-Jean Shon, Hye Jin Kang, Eun-Suk Choi, Young Ki Peck, Kyong Ran |
author_facet | Ko, Jae-Hoon Joo, Eun-Jeong Park, Su-Jin Baek, Jin Yang Kim, Won Duk Jee, Jaehwan Kim, Chul Joong Jeong, Chul Kim, Yae-Jean Shon, Hye Jin Kang, Eun-Suk Choi, Young Ki Peck, Kyong Ran |
author_sort | Ko, Jae-Hoon |
collection | PubMed |
description | Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A total of 70 laboratory-confirmed COVID-19 patients were evaluated, including 15 asymptomatic/anosmia, 49 mild symptomatic, and 6 pneumonia patients. The production of the neutralizing antibody was observed in 100% of pneumonia, 93.9% of mild symptomatic, and 80.0% of asymptomatic/anosmia groups. All the patients in the pneumonia group showed high MN titer (≥1:80), while 36.7% of mild symptomatic and 20.0% of asymptomatic/anosmia groups showed high titer (p < 0.001). Anti-SARS-CoV-2 antibodies could be more sensitively detected by FIA IgG (98.8%) and ELISA (97.6%) in overall. For the FIA IgG test, all patients in the pneumonia group exhibited a high COI value (≥15.0), while 89.8% of mild symptomatic and 73.3% of asymptomatic/anosmia groups showed a high value (p = 0.049). For the ELISA test, all patients in the pneumonia group showed a high optical density (OD) ratio (≥3.0), while 65.3% of mild symptomatic and 53.3% of asymptomatic/anosmia groups showed a high ratio (p = 0.006). Conclusions: Most asymptomatic and mild COVID-19 patients produced the neutralizing antibody, although the titers were lower than pneumonia patients. ELISA and FIA sensitively detected anti-SARS-CoV-2 antibodies. |
format | Online Article Text |
id | pubmed-7408950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74089502020-08-13 Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients Ko, Jae-Hoon Joo, Eun-Jeong Park, Su-Jin Baek, Jin Yang Kim, Won Duk Jee, Jaehwan Kim, Chul Joong Jeong, Chul Kim, Yae-Jean Shon, Hye Jin Kang, Eun-Suk Choi, Young Ki Peck, Kyong Ran J Clin Med Article Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A total of 70 laboratory-confirmed COVID-19 patients were evaluated, including 15 asymptomatic/anosmia, 49 mild symptomatic, and 6 pneumonia patients. The production of the neutralizing antibody was observed in 100% of pneumonia, 93.9% of mild symptomatic, and 80.0% of asymptomatic/anosmia groups. All the patients in the pneumonia group showed high MN titer (≥1:80), while 36.7% of mild symptomatic and 20.0% of asymptomatic/anosmia groups showed high titer (p < 0.001). Anti-SARS-CoV-2 antibodies could be more sensitively detected by FIA IgG (98.8%) and ELISA (97.6%) in overall. For the FIA IgG test, all patients in the pneumonia group exhibited a high COI value (≥15.0), while 89.8% of mild symptomatic and 73.3% of asymptomatic/anosmia groups showed a high value (p = 0.049). For the ELISA test, all patients in the pneumonia group showed a high optical density (OD) ratio (≥3.0), while 65.3% of mild symptomatic and 53.3% of asymptomatic/anosmia groups showed a high ratio (p = 0.006). Conclusions: Most asymptomatic and mild COVID-19 patients produced the neutralizing antibody, although the titers were lower than pneumonia patients. ELISA and FIA sensitively detected anti-SARS-CoV-2 antibodies. MDPI 2020-07-17 /pmc/articles/PMC7408950/ /pubmed/32708872 http://dx.doi.org/10.3390/jcm9072268 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Jae-Hoon Joo, Eun-Jeong Park, Su-Jin Baek, Jin Yang Kim, Won Duk Jee, Jaehwan Kim, Chul Joong Jeong, Chul Kim, Yae-Jean Shon, Hye Jin Kang, Eun-Suk Choi, Young Ki Peck, Kyong Ran Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title | Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title_full | Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title_fullStr | Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title_full_unstemmed | Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title_short | Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients |
title_sort | neutralizing antibody production in asymptomatic and mild covid-19 patients, in comparison with pneumonic covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408950/ https://www.ncbi.nlm.nih.gov/pubmed/32708872 http://dx.doi.org/10.3390/jcm9072268 |
work_keys_str_mv | AT kojaehoon neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT jooeunjeong neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT parksujin neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT baekjinyang neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT kimwonduk neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT jeejaehwan neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT kimchuljoong neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT jeongchul neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT kimyaejean neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT shonhyejin neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT kangeunsuk neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT choiyoungki neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients AT peckkyongran neutralizingantibodyproductioninasymptomaticandmildcovid19patientsincomparisonwithpneumoniccovid19patients |