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Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients

Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A to...

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Autores principales: Ko, Jae-Hoon, Joo, Eun-Jeong, Park, Su-Jin, Baek, Jin Yang, Kim, Won Duk, Jee, Jaehwan, Kim, Chul Joong, Jeong, Chul, Kim, Yae-Jean, Shon, Hye Jin, Kang, Eun-Suk, Choi, Young Ki, Peck, Kyong Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408950/
https://www.ncbi.nlm.nih.gov/pubmed/32708872
http://dx.doi.org/10.3390/jcm9072268
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author Ko, Jae-Hoon
Joo, Eun-Jeong
Park, Su-Jin
Baek, Jin Yang
Kim, Won Duk
Jee, Jaehwan
Kim, Chul Joong
Jeong, Chul
Kim, Yae-Jean
Shon, Hye Jin
Kang, Eun-Suk
Choi, Young Ki
Peck, Kyong Ran
author_facet Ko, Jae-Hoon
Joo, Eun-Jeong
Park, Su-Jin
Baek, Jin Yang
Kim, Won Duk
Jee, Jaehwan
Kim, Chul Joong
Jeong, Chul
Kim, Yae-Jean
Shon, Hye Jin
Kang, Eun-Suk
Choi, Young Ki
Peck, Kyong Ran
author_sort Ko, Jae-Hoon
collection PubMed
description Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A total of 70 laboratory-confirmed COVID-19 patients were evaluated, including 15 asymptomatic/anosmia, 49 mild symptomatic, and 6 pneumonia patients. The production of the neutralizing antibody was observed in 100% of pneumonia, 93.9% of mild symptomatic, and 80.0% of asymptomatic/anosmia groups. All the patients in the pneumonia group showed high MN titer (≥1:80), while 36.7% of mild symptomatic and 20.0% of asymptomatic/anosmia groups showed high titer (p < 0.001). Anti-SARS-CoV-2 antibodies could be more sensitively detected by FIA IgG (98.8%) and ELISA (97.6%) in overall. For the FIA IgG test, all patients in the pneumonia group exhibited a high COI value (≥15.0), while 89.8% of mild symptomatic and 73.3% of asymptomatic/anosmia groups showed a high value (p = 0.049). For the ELISA test, all patients in the pneumonia group showed a high optical density (OD) ratio (≥3.0), while 65.3% of mild symptomatic and 53.3% of asymptomatic/anosmia groups showed a high ratio (p = 0.006). Conclusions: Most asymptomatic and mild COVID-19 patients produced the neutralizing antibody, although the titers were lower than pneumonia patients. ELISA and FIA sensitively detected anti-SARS-CoV-2 antibodies.
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spelling pubmed-74089502020-08-13 Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients Ko, Jae-Hoon Joo, Eun-Jeong Park, Su-Jin Baek, Jin Yang Kim, Won Duk Jee, Jaehwan Kim, Chul Joong Jeong, Chul Kim, Yae-Jean Shon, Hye Jin Kang, Eun-Suk Choi, Young Ki Peck, Kyong Ran J Clin Med Article Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A total of 70 laboratory-confirmed COVID-19 patients were evaluated, including 15 asymptomatic/anosmia, 49 mild symptomatic, and 6 pneumonia patients. The production of the neutralizing antibody was observed in 100% of pneumonia, 93.9% of mild symptomatic, and 80.0% of asymptomatic/anosmia groups. All the patients in the pneumonia group showed high MN titer (≥1:80), while 36.7% of mild symptomatic and 20.0% of asymptomatic/anosmia groups showed high titer (p < 0.001). Anti-SARS-CoV-2 antibodies could be more sensitively detected by FIA IgG (98.8%) and ELISA (97.6%) in overall. For the FIA IgG test, all patients in the pneumonia group exhibited a high COI value (≥15.0), while 89.8% of mild symptomatic and 73.3% of asymptomatic/anosmia groups showed a high value (p = 0.049). For the ELISA test, all patients in the pneumonia group showed a high optical density (OD) ratio (≥3.0), while 65.3% of mild symptomatic and 53.3% of asymptomatic/anosmia groups showed a high ratio (p = 0.006). Conclusions: Most asymptomatic and mild COVID-19 patients produced the neutralizing antibody, although the titers were lower than pneumonia patients. ELISA and FIA sensitively detected anti-SARS-CoV-2 antibodies. MDPI 2020-07-17 /pmc/articles/PMC7408950/ /pubmed/32708872 http://dx.doi.org/10.3390/jcm9072268 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Jae-Hoon
Joo, Eun-Jeong
Park, Su-Jin
Baek, Jin Yang
Kim, Won Duk
Jee, Jaehwan
Kim, Chul Joong
Jeong, Chul
Kim, Yae-Jean
Shon, Hye Jin
Kang, Eun-Suk
Choi, Young Ki
Peck, Kyong Ran
Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title_full Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title_fullStr Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title_full_unstemmed Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title_short Neutralizing Antibody Production in Asymptomatic and Mild COVID-19 Patients, in Comparison with Pneumonic COVID-19 Patients
title_sort neutralizing antibody production in asymptomatic and mild covid-19 patients, in comparison with pneumonic covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408950/
https://www.ncbi.nlm.nih.gov/pubmed/32708872
http://dx.doi.org/10.3390/jcm9072268
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