Hormones Secretion and Rho GTPases in Neuroendocrine Tumors

Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled...

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Autores principales: Streit, Laura, Brunaud, Laurent, Vitale, Nicolas, Ory, Stéphane, Gasman, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408961/
https://www.ncbi.nlm.nih.gov/pubmed/32664294
http://dx.doi.org/10.3390/cancers12071859
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author Streit, Laura
Brunaud, Laurent
Vitale, Nicolas
Ory, Stéphane
Gasman, Stéphane
author_facet Streit, Laura
Brunaud, Laurent
Vitale, Nicolas
Ory, Stéphane
Gasman, Stéphane
author_sort Streit, Laura
collection PubMed
description Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion.
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spelling pubmed-74089612020-08-26 Hormones Secretion and Rho GTPases in Neuroendocrine Tumors Streit, Laura Brunaud, Laurent Vitale, Nicolas Ory, Stéphane Gasman, Stéphane Cancers (Basel) Review Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion. MDPI 2020-07-10 /pmc/articles/PMC7408961/ /pubmed/32664294 http://dx.doi.org/10.3390/cancers12071859 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Streit, Laura
Brunaud, Laurent
Vitale, Nicolas
Ory, Stéphane
Gasman, Stéphane
Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title_full Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title_fullStr Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title_full_unstemmed Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title_short Hormones Secretion and Rho GTPases in Neuroendocrine Tumors
title_sort hormones secretion and rho gtpases in neuroendocrine tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408961/
https://www.ncbi.nlm.nih.gov/pubmed/32664294
http://dx.doi.org/10.3390/cancers12071859
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AT orystephane hormonessecretionandrhogtpasesinneuroendocrinetumors
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