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Epidemiological and clinical features of pediatric COVID-19
BACKGROUND: COVID-19 is an extremely severe infectious disease. However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. This study conducted a retrospective review of the epidemiological and clinical features of COVID-19 in children. METHODS: A re...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408975/ https://www.ncbi.nlm.nih.gov/pubmed/32762696 http://dx.doi.org/10.1186/s12916-020-01719-2 |
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author | Guo, Cheng-Xian He, Li Yin, Ji-Ye Meng, Xiang-Guang Tan, Wei Yang, Guo-Ping Bo, Tao Liu, Jun-Ping Lin, Xin-Jian Chen, Xiang |
author_facet | Guo, Cheng-Xian He, Li Yin, Ji-Ye Meng, Xiang-Guang Tan, Wei Yang, Guo-Ping Bo, Tao Liu, Jun-Ping Lin, Xin-Jian Chen, Xiang |
author_sort | Guo, Cheng-Xian |
collection | PubMed |
description | BACKGROUND: COVID-19 is an extremely severe infectious disease. However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. This study conducted a retrospective review of the epidemiological and clinical features of COVID-19 in children. METHODS: A retrospective study was conducted on children with a definite diagnosis of COVID-19 in mainland China using the web crawler technique to collect anonymous COVID-19 updates published by local health authorities. RESULTS: Three hundred forty-one children aged 4 days to 14 years with a median age of 7 years were included. Sixty-six percent of pediatric patients were infected via family members with COVID-19. The median incubation period was 9 days (interquartile range, 6 to 13). Asymptomatic cases accounted for 5.9%, of which 30% had abnormal chest radiologic findings. A majority of pediatric COVID-19 cases showed mild to moderate clinical features, and only a few developed severe or critical diseases (0.6% and 0.3%, respectively). Fever (77.9%) and cough (32.4%) were the predominant presenting symptoms of pediatric COVID-19. The pediatric patients had fewer underlying diseases and complications than adults. The treatment modalities for pediatric COVID-19 patients were not as complex as those of adult COVID-19 patients. The overall prognosis of pediatric COVID-19 was benign with a decent recovery. The median time from onset to cure was 16 days (interquartile range, 13 to 21). CONCLUSIONS: Compared to adults, COVID-19 in children has distinct features of epidemiology and clinical manifestations. The findings from this study might help to guide the development of measures to prevent and treat this ongoing global pandemic. TRIAL REGISTRATION: Chinese Clinical Trial Registry (chictr.org.cn) identifier: ChiCTR2000030464. |
format | Online Article Text |
id | pubmed-7408975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74089752020-08-07 Epidemiological and clinical features of pediatric COVID-19 Guo, Cheng-Xian He, Li Yin, Ji-Ye Meng, Xiang-Guang Tan, Wei Yang, Guo-Ping Bo, Tao Liu, Jun-Ping Lin, Xin-Jian Chen, Xiang BMC Med Research Article BACKGROUND: COVID-19 is an extremely severe infectious disease. However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. This study conducted a retrospective review of the epidemiological and clinical features of COVID-19 in children. METHODS: A retrospective study was conducted on children with a definite diagnosis of COVID-19 in mainland China using the web crawler technique to collect anonymous COVID-19 updates published by local health authorities. RESULTS: Three hundred forty-one children aged 4 days to 14 years with a median age of 7 years were included. Sixty-six percent of pediatric patients were infected via family members with COVID-19. The median incubation period was 9 days (interquartile range, 6 to 13). Asymptomatic cases accounted for 5.9%, of which 30% had abnormal chest radiologic findings. A majority of pediatric COVID-19 cases showed mild to moderate clinical features, and only a few developed severe or critical diseases (0.6% and 0.3%, respectively). Fever (77.9%) and cough (32.4%) were the predominant presenting symptoms of pediatric COVID-19. The pediatric patients had fewer underlying diseases and complications than adults. The treatment modalities for pediatric COVID-19 patients were not as complex as those of adult COVID-19 patients. The overall prognosis of pediatric COVID-19 was benign with a decent recovery. The median time from onset to cure was 16 days (interquartile range, 13 to 21). CONCLUSIONS: Compared to adults, COVID-19 in children has distinct features of epidemiology and clinical manifestations. The findings from this study might help to guide the development of measures to prevent and treat this ongoing global pandemic. TRIAL REGISTRATION: Chinese Clinical Trial Registry (chictr.org.cn) identifier: ChiCTR2000030464. BioMed Central 2020-08-06 /pmc/articles/PMC7408975/ /pubmed/32762696 http://dx.doi.org/10.1186/s12916-020-01719-2 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Guo, Cheng-Xian He, Li Yin, Ji-Ye Meng, Xiang-Guang Tan, Wei Yang, Guo-Ping Bo, Tao Liu, Jun-Ping Lin, Xin-Jian Chen, Xiang Epidemiological and clinical features of pediatric COVID-19 |
title | Epidemiological and clinical features of pediatric COVID-19 |
title_full | Epidemiological and clinical features of pediatric COVID-19 |
title_fullStr | Epidemiological and clinical features of pediatric COVID-19 |
title_full_unstemmed | Epidemiological and clinical features of pediatric COVID-19 |
title_short | Epidemiological and clinical features of pediatric COVID-19 |
title_sort | epidemiological and clinical features of pediatric covid-19 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408975/ https://www.ncbi.nlm.nih.gov/pubmed/32762696 http://dx.doi.org/10.1186/s12916-020-01719-2 |
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