Cargando…
Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon canc...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408996/ https://www.ncbi.nlm.nih.gov/pubmed/32664289 http://dx.doi.org/10.3390/jcm9072181 |
_version_ | 1783567961768853504 |
---|---|
author | Park, In Ja Lee, Ju-Hoon Kye, Bong-Hyeon Oh, Heung-Kwon Cho, Yong Beom Kim, You-Tae Kim, Joo Yun Sung, Na Young Kang, Sung-Bum Seo, Jeong-Meen Sim, Jae-Hun Lee, Jung-Lyoul Lee, In Kyu |
author_facet | Park, In Ja Lee, Ju-Hoon Kye, Bong-Hyeon Oh, Heung-Kwon Cho, Yong Beom Kim, You-Tae Kim, Joo Yun Sung, Na Young Kang, Sung-Bum Seo, Jeong-Meen Sim, Jae-Hun Lee, Jung-Lyoul Lee, In Kyu |
author_sort | Park, In Ja |
collection | PubMed |
description | We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon cancer resection, 60 were eligible, of whom 29 and 31 received probiotics and placebo, respectively, for four weeks, starting at one week preoperatively. Third- and/or fourth-week information on anterior resection syndrome (ARS), inflammatory markers, and quality of life was obtained. Stool sample analysis was conducted after randomization and bowel preparation and at three and four postoperative weeks. Bacteria were categorized into Set I (with probiotic effects) and II (colon cancer-associated). The probiotic group’s ARS score showed an improving trend (p = 0.063), particularly for flatus control (p = 0.030). Serum zonulin levels significantly decreased with probiotics. Probiotic ingestion resulted in compositional changes in gut microbiota; greater increases and decreases in Set I and II bacteria, respectively, occurred with probiotics. Compositional increase in Set I bacteria was associated with reduced white blood cells, neutrophils, neutrophil-lymphocyte ratio, and zonulin. Bifidobacterium composition was negatively correlated with zonulin levels in the probiotic group. Probiotics improved postoperative flatus control and modified postoperative changes in microbiota and inflammatory markers. |
format | Online Article Text |
id | pubmed-7408996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74089962020-08-26 Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial Park, In Ja Lee, Ju-Hoon Kye, Bong-Hyeon Oh, Heung-Kwon Cho, Yong Beom Kim, You-Tae Kim, Joo Yun Sung, Na Young Kang, Sung-Bum Seo, Jeong-Meen Sim, Jae-Hun Lee, Jung-Lyoul Lee, In Kyu J Clin Med Article We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon cancer resection, 60 were eligible, of whom 29 and 31 received probiotics and placebo, respectively, for four weeks, starting at one week preoperatively. Third- and/or fourth-week information on anterior resection syndrome (ARS), inflammatory markers, and quality of life was obtained. Stool sample analysis was conducted after randomization and bowel preparation and at three and four postoperative weeks. Bacteria were categorized into Set I (with probiotic effects) and II (colon cancer-associated). The probiotic group’s ARS score showed an improving trend (p = 0.063), particularly for flatus control (p = 0.030). Serum zonulin levels significantly decreased with probiotics. Probiotic ingestion resulted in compositional changes in gut microbiota; greater increases and decreases in Set I and II bacteria, respectively, occurred with probiotics. Compositional increase in Set I bacteria was associated with reduced white blood cells, neutrophils, neutrophil-lymphocyte ratio, and zonulin. Bifidobacterium composition was negatively correlated with zonulin levels in the probiotic group. Probiotics improved postoperative flatus control and modified postoperative changes in microbiota and inflammatory markers. MDPI 2020-07-10 /pmc/articles/PMC7408996/ /pubmed/32664289 http://dx.doi.org/10.3390/jcm9072181 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, In Ja Lee, Ju-Hoon Kye, Bong-Hyeon Oh, Heung-Kwon Cho, Yong Beom Kim, You-Tae Kim, Joo Yun Sung, Na Young Kang, Sung-Bum Seo, Jeong-Meen Sim, Jae-Hun Lee, Jung-Lyoul Lee, In Kyu Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title_fullStr | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full_unstemmed | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title_short | Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial |
title_sort | effects of probiotics on the symptoms and surgical outcomes after anterior resection of colon cancer (postcare): a randomized, double-blind, placebo-controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408996/ https://www.ncbi.nlm.nih.gov/pubmed/32664289 http://dx.doi.org/10.3390/jcm9072181 |
work_keys_str_mv | AT parkinja effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT leejuhoon effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT kyebonghyeon effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT ohheungkwon effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT choyongbeom effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT kimyoutae effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT kimjooyun effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT sungnayoung effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT kangsungbum effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT seojeongmeen effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT simjaehun effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT leejunglyoul effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial AT leeinkyu effectsofprobioticsonthesymptomsandsurgicaloutcomesafteranteriorresectionofcoloncancerpostcarearandomizeddoubleblindplacebocontrolledtrial |