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Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial

We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon canc...

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Autores principales: Park, In Ja, Lee, Ju-Hoon, Kye, Bong-Hyeon, Oh, Heung-Kwon, Cho, Yong Beom, Kim, You-Tae, Kim, Joo Yun, Sung, Na Young, Kang, Sung-Bum, Seo, Jeong-Meen, Sim, Jae-Hun, Lee, Jung-Lyoul, Lee, In Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408996/
https://www.ncbi.nlm.nih.gov/pubmed/32664289
http://dx.doi.org/10.3390/jcm9072181
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author Park, In Ja
Lee, Ju-Hoon
Kye, Bong-Hyeon
Oh, Heung-Kwon
Cho, Yong Beom
Kim, You-Tae
Kim, Joo Yun
Sung, Na Young
Kang, Sung-Bum
Seo, Jeong-Meen
Sim, Jae-Hun
Lee, Jung-Lyoul
Lee, In Kyu
author_facet Park, In Ja
Lee, Ju-Hoon
Kye, Bong-Hyeon
Oh, Heung-Kwon
Cho, Yong Beom
Kim, You-Tae
Kim, Joo Yun
Sung, Na Young
Kang, Sung-Bum
Seo, Jeong-Meen
Sim, Jae-Hun
Lee, Jung-Lyoul
Lee, In Kyu
author_sort Park, In Ja
collection PubMed
description We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon cancer resection, 60 were eligible, of whom 29 and 31 received probiotics and placebo, respectively, for four weeks, starting at one week preoperatively. Third- and/or fourth-week information on anterior resection syndrome (ARS), inflammatory markers, and quality of life was obtained. Stool sample analysis was conducted after randomization and bowel preparation and at three and four postoperative weeks. Bacteria were categorized into Set I (with probiotic effects) and II (colon cancer-associated). The probiotic group’s ARS score showed an improving trend (p = 0.063), particularly for flatus control (p = 0.030). Serum zonulin levels significantly decreased with probiotics. Probiotic ingestion resulted in compositional changes in gut microbiota; greater increases and decreases in Set I and II bacteria, respectively, occurred with probiotics. Compositional increase in Set I bacteria was associated with reduced white blood cells, neutrophils, neutrophil-lymphocyte ratio, and zonulin. Bifidobacterium composition was negatively correlated with zonulin levels in the probiotic group. Probiotics improved postoperative flatus control and modified postoperative changes in microbiota and inflammatory markers.
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spelling pubmed-74089962020-08-26 Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial Park, In Ja Lee, Ju-Hoon Kye, Bong-Hyeon Oh, Heung-Kwon Cho, Yong Beom Kim, You-Tae Kim, Joo Yun Sung, Na Young Kang, Sung-Bum Seo, Jeong-Meen Sim, Jae-Hun Lee, Jung-Lyoul Lee, In Kyu J Clin Med Article We investigated microbiota changes following surgical colon cancer resection and evaluate effects of probiotics on microbiota and surgical recovery. This randomized double-blind trial was performed at four medical centers in South Korea. Of 68 patients expected to undergo anterior sigmoid colon cancer resection, 60 were eligible, of whom 29 and 31 received probiotics and placebo, respectively, for four weeks, starting at one week preoperatively. Third- and/or fourth-week information on anterior resection syndrome (ARS), inflammatory markers, and quality of life was obtained. Stool sample analysis was conducted after randomization and bowel preparation and at three and four postoperative weeks. Bacteria were categorized into Set I (with probiotic effects) and II (colon cancer-associated). The probiotic group’s ARS score showed an improving trend (p = 0.063), particularly for flatus control (p = 0.030). Serum zonulin levels significantly decreased with probiotics. Probiotic ingestion resulted in compositional changes in gut microbiota; greater increases and decreases in Set I and II bacteria, respectively, occurred with probiotics. Compositional increase in Set I bacteria was associated with reduced white blood cells, neutrophils, neutrophil-lymphocyte ratio, and zonulin. Bifidobacterium composition was negatively correlated with zonulin levels in the probiotic group. Probiotics improved postoperative flatus control and modified postoperative changes in microbiota and inflammatory markers. MDPI 2020-07-10 /pmc/articles/PMC7408996/ /pubmed/32664289 http://dx.doi.org/10.3390/jcm9072181 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, In Ja
Lee, Ju-Hoon
Kye, Bong-Hyeon
Oh, Heung-Kwon
Cho, Yong Beom
Kim, You-Tae
Kim, Joo Yun
Sung, Na Young
Kang, Sung-Bum
Seo, Jeong-Meen
Sim, Jae-Hun
Lee, Jung-Lyoul
Lee, In Kyu
Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title_full Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title_fullStr Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title_full_unstemmed Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title_short Effects of PrObiotics on the Symptoms and Surgical ouTComes after Anterior REsection of Colon Cancer (POSTCARE): A Randomized, Double-Blind, Placebo-Controlled Trial
title_sort effects of probiotics on the symptoms and surgical outcomes after anterior resection of colon cancer (postcare): a randomized, double-blind, placebo-controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408996/
https://www.ncbi.nlm.nih.gov/pubmed/32664289
http://dx.doi.org/10.3390/jcm9072181
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