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The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile

High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. This overall profile of the response depends on the inducing event and can...

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Autores principales: Aarstad, Helene Hersvik, Guðbrandsdottir, Gigja, Hjelle, Karin M., Bostad, Leif, Bruserud, Øystein, Tvedt, Tor Henrik Anderson, Beisland, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409073/
https://www.ncbi.nlm.nih.gov/pubmed/32707675
http://dx.doi.org/10.3390/cancers12071961
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author Aarstad, Helene Hersvik
Guðbrandsdottir, Gigja
Hjelle, Karin M.
Bostad, Leif
Bruserud, Øystein
Tvedt, Tor Henrik Anderson
Beisland, Christian
author_facet Aarstad, Helene Hersvik
Guðbrandsdottir, Gigja
Hjelle, Karin M.
Bostad, Leif
Bruserud, Øystein
Tvedt, Tor Henrik Anderson
Beisland, Christian
author_sort Aarstad, Helene Hersvik
collection PubMed
description High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. This overall profile of the response depends on the inducing event and can also differ between patients. We investigated an extended acute phase cytokine profile for 97 renal cancer patients. Initial studies showed that the serum CRP levels had an expected prognostic association together with tumor size, stage, nuclear grading, and Leibovich score. Interleukin (IL)6 family cytokines, IL1 subfamily mediators, and tumor necrosis factor (TNF)α can all be drivers of the acute phase response. Initial studies suggested that serum IL33Rα (the soluble IL33 receptor α chain) levels were also associated with prognosis, although the impact of IL33Rα is dependent on the overall cytokine profile, including seven IL6 family members (IL6, IL6Rα, gp130, IL27, IL31, CNTF, and OSM), two IL1 subfamily members (IL1RA and IL33Rα), and TNFα. We identified a patient subset characterized by particularly high levels of IL6, IL33Rα, and TNFα alongside an adverse prognosis. Thus, the acute phase cytokine reaction differs between renal cancer patients, and differences in the acute phase cytokine profile are associated with prognosis.
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spelling pubmed-74090732020-08-26 The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile Aarstad, Helene Hersvik Guðbrandsdottir, Gigja Hjelle, Karin M. Bostad, Leif Bruserud, Øystein Tvedt, Tor Henrik Anderson Beisland, Christian Cancers (Basel) Article High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. This overall profile of the response depends on the inducing event and can also differ between patients. We investigated an extended acute phase cytokine profile for 97 renal cancer patients. Initial studies showed that the serum CRP levels had an expected prognostic association together with tumor size, stage, nuclear grading, and Leibovich score. Interleukin (IL)6 family cytokines, IL1 subfamily mediators, and tumor necrosis factor (TNF)α can all be drivers of the acute phase response. Initial studies suggested that serum IL33Rα (the soluble IL33 receptor α chain) levels were also associated with prognosis, although the impact of IL33Rα is dependent on the overall cytokine profile, including seven IL6 family members (IL6, IL6Rα, gp130, IL27, IL31, CNTF, and OSM), two IL1 subfamily members (IL1RA and IL33Rα), and TNFα. We identified a patient subset characterized by particularly high levels of IL6, IL33Rα, and TNFα alongside an adverse prognosis. Thus, the acute phase cytokine reaction differs between renal cancer patients, and differences in the acute phase cytokine profile are associated with prognosis. MDPI 2020-07-19 /pmc/articles/PMC7409073/ /pubmed/32707675 http://dx.doi.org/10.3390/cancers12071961 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aarstad, Helene Hersvik
Guðbrandsdottir, Gigja
Hjelle, Karin M.
Bostad, Leif
Bruserud, Øystein
Tvedt, Tor Henrik Anderson
Beisland, Christian
The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title_full The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title_fullStr The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title_full_unstemmed The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title_short The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
title_sort biological context of c-reactive protein as a prognostic marker in renal cell carcinoma: studies on the acute phase cytokine profile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409073/
https://www.ncbi.nlm.nih.gov/pubmed/32707675
http://dx.doi.org/10.3390/cancers12071961
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