Cargando…

Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development

Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-mediated destruction of insulin-producing β-cells. The concordance rate for T1D in monozygotic twins is ≈30–50%, indicating that environmental factors also play a role in T1D development. Previous studies have demonstrat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blum, Samuel I., Tse, Hubert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409145/ https://www.ncbi.nlm.nih.gov/pubmed/32635205 http://dx.doi.org/10.3390/microorganisms8070993

Ejemplares similares

MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance
por: Blum, Samuel I., et al.
Publicado: (2023)

Pigeon MDA5 inhibits viral replication by triggering antiviral innate immunity
por: Shao, Qi, et al.
Publicado: (2023)

Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection
por: Li, Jing, et al.
Publicado: (2023)

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors
por: Nigi, Laura, et al.
Publicado: (2022)

Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion
por: Wang, Shao-Hua, et al.
Publicado: (2023)

Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity
por: Lee, Chih-Chun, et al.
Publicado: (2014)

RIG-I– and MDA5-Initiated Innate Immunity Linked With Adaptive Immunity Accelerates β-Cell Death in Fulminant Type 1 Diabetes
por: Aida, Kaoru, et al.
Publicado: (2011)

Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection
por: Fischer, Heinz, et al.
Publicado: (2020)

Coxsackievirus A6 Induces Necroptosis for Viral Production
por: Zhang, Shuxia, et al.
Publicado: (2020)

Atomic Structures of Coxsackievirus B5 Provide Key Information on Viral Evolution and Survival
por: Yang, Peng, et al.
Publicado: (2022)

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
por: Lang, Xueting, et al.
Publicado: (2017)

Immune mechanisms of group B coxsackievirus induced viral myocarditis
por: Zhang, Yue, et al.
Publicado: (2023)

Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis
por: Niu, Chengrui, et al.
Publicado: (2023)

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
por: Nekoua, Magloire Pandoua, et al.
Publicado: (2022)

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5
por: Hu, Ming-Ming, et al.
Publicado: (2017)

ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response
por: Zhong, Xuan, et al.
Publicado: (2020)

Bat Employs a Conserved MDA5 Gene to Trigger Antiviral Innate Immune Responses
por: Wang, Jie, et al.
Publicado: (2022)

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo
por: Gitlin, Leonid, et al.
Publicado: (2010)

The RNA sensor MDA5 detects SARS-CoV-2 infection
por: Sampaio, Natalia G., et al.
Publicado: (2021)

Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5
por: Kim, Hyejin, et al.
Publicado: (2021)

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
por: Yin, Xin, et al.
Publicado: (2021)

How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?
por: Michaux, Hélène, et al.
Publicado: (2015)

Cinnamaldehyde Derivatives Inhibit Coxsackievirus B3-Induced Viral Myocarditis
por: Li, Xiao-Qiang, et al.
Publicado: (2017)

Coxsackievirus B3 infection induces glycolysis to facilitate viral replication
por: Qian, Yujie, et al.
Publicado: (2022)

Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism
por: Fu, Yuxuan, et al.
Publicado: (2023)

Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset
por: Morse, Zachary J., et al.
Publicado: (2017)

Etymologia: Coxsackievirus
Publicado: (2012)

COXSACKIEVIRUSES (PICORNAVIRIDAE)
por: Pozzetto, Bruno, et al.
Publicado: (1999)

Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations
por: Chan, Chi-Ping, et al.
Publicado: (2022)

Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells
por: Wang, Shu-Qing, et al.
Publicado: (2019)

Transcriptomic profiling and longitudinal study reveal the relationship of anti-MDA5 titer and type I IFN signature in MDA5+ dermatomyositis
por: Wang, Yan, et al.
Publicado: (2023)

Induction of Innate Immune Responses by SIV In Vivo and In Vitro: Differential Expression and Function of RIG-I and MDA5
por: Co, Juliene G., et al.
Publicado: (2011)

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium
por: Slater, Louise, et al.
Publicado: (2010)

MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
por: Bullen, C. Korin, et al.
Publicado: (2023)

IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis
por: Yu, Miao, et al.
Publicado: (2016)

Coxsackievirus B3 Exploits the Ubiquitin-Proteasome System to Facilitate Viral Replication
por: Voss, Martin, et al.
Publicado: (2021)

Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding
por: Lin, Chien-Ju, et al.
Publicado: (2018)

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

The Interplay Between Innate-Like B Cells and Other Cell Types in Autoimmunity
por: Tsay, Gregory J., et al.
Publicado: (2018)

Interplay Between Liver Type 1 Innate Lymphoid Cells and NK Cells Drives the Development of Alcoholic Steatohepatitis
por: Cheng, Chen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hmf7to426hq4ilpbl8u7geq7qc