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Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy

The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outb...

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Autores principales: Cavagna, Lorenzo, Seminari, Elena, Zanframundo, Giovanni, Gregorini, Marilena, Di Matteo, Angela, Rampino, Teresa, Montecucco, Carlomaurizio, Pelenghi, Stefano, Cattadori, Barbara, Pattonieri, Eleonora Francesca, Vitulo, Patrizio, Bertani, Alessandro, Sambataro, Gianluca, Vancheri, Carlo, Biglia, Alessandro, Bozzalla-Cassione, Emanuele, Bonetto, Valentina, Monti, Maria Cristina, Ticozzelli, Elena, Turco, Annalisa, Oggionni, Tiberio, Corsico, Angelo, Bertuccio, Francesco, Zuccaro, Valentina, Codullo, Veronica, Morosini, Monica, Marena, Carlo, Gnecchi, Massimiliano, Pellegrini, Carlo, Meloni, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409165/
https://www.ncbi.nlm.nih.gov/pubmed/32629788
http://dx.doi.org/10.3390/microorganisms8070977
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author Cavagna, Lorenzo
Seminari, Elena
Zanframundo, Giovanni
Gregorini, Marilena
Di Matteo, Angela
Rampino, Teresa
Montecucco, Carlomaurizio
Pelenghi, Stefano
Cattadori, Barbara
Pattonieri, Eleonora Francesca
Vitulo, Patrizio
Bertani, Alessandro
Sambataro, Gianluca
Vancheri, Carlo
Biglia, Alessandro
Bozzalla-Cassione, Emanuele
Bonetto, Valentina
Monti, Maria Cristina
Ticozzelli, Elena
Turco, Annalisa
Oggionni, Tiberio
Corsico, Angelo
Bertuccio, Francesco
Zuccaro, Valentina
Codullo, Veronica
Morosini, Monica
Marena, Carlo
Gnecchi, Massimiliano
Pellegrini, Carlo
Meloni, Federica
author_facet Cavagna, Lorenzo
Seminari, Elena
Zanframundo, Giovanni
Gregorini, Marilena
Di Matteo, Angela
Rampino, Teresa
Montecucco, Carlomaurizio
Pelenghi, Stefano
Cattadori, Barbara
Pattonieri, Eleonora Francesca
Vitulo, Patrizio
Bertani, Alessandro
Sambataro, Gianluca
Vancheri, Carlo
Biglia, Alessandro
Bozzalla-Cassione, Emanuele
Bonetto, Valentina
Monti, Maria Cristina
Ticozzelli, Elena
Turco, Annalisa
Oggionni, Tiberio
Corsico, Angelo
Bertuccio, Francesco
Zuccaro, Valentina
Codullo, Veronica
Morosini, Monica
Marena, Carlo
Gnecchi, Massimiliano
Pellegrini, Carlo
Meloni, Federica
author_sort Cavagna, Lorenzo
collection PubMed
description The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outbreak in Italy up to 28 April 2020. Patients were followed at our hospital for solid organ transplantation or systemic rheumatic disorders (RMDs) and were on calcineurin inhibitor (CNI)-based therapy. Selected patients were referred from the North of Italy. The aim of our study was to evaluate the clinical course of COVID-19 in this setting. We evaluated 385 consecutive patients (220 males, 57%; median age 61 years, IQR 48–69); 331 (86%) received solid organ transplantation and 54 (14%) had a RMD. CNIs were the only immunosuppressant administered in 47 patients (12%). We identified 14 (4%) COVID-19 patients, all transplanted, mainly presenting with fever (86%) and diarrhea (71%). Twelve patients were hospitalized and two of them died, both with severe comorbidities. No patients developed acute respiratory distress syndrome or infectious complications. The surviving 10 patients are now fully recovered. The clinical course of COVID-19 patients on CNIs is generally mild, and the risk of superinfection seems low.
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spelling pubmed-74091652020-08-26 Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy Cavagna, Lorenzo Seminari, Elena Zanframundo, Giovanni Gregorini, Marilena Di Matteo, Angela Rampino, Teresa Montecucco, Carlomaurizio Pelenghi, Stefano Cattadori, Barbara Pattonieri, Eleonora Francesca Vitulo, Patrizio Bertani, Alessandro Sambataro, Gianluca Vancheri, Carlo Biglia, Alessandro Bozzalla-Cassione, Emanuele Bonetto, Valentina Monti, Maria Cristina Ticozzelli, Elena Turco, Annalisa Oggionni, Tiberio Corsico, Angelo Bertuccio, Francesco Zuccaro, Valentina Codullo, Veronica Morosini, Monica Marena, Carlo Gnecchi, Massimiliano Pellegrini, Carlo Meloni, Federica Microorganisms Communication The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outbreak in Italy up to 28 April 2020. Patients were followed at our hospital for solid organ transplantation or systemic rheumatic disorders (RMDs) and were on calcineurin inhibitor (CNI)-based therapy. Selected patients were referred from the North of Italy. The aim of our study was to evaluate the clinical course of COVID-19 in this setting. We evaluated 385 consecutive patients (220 males, 57%; median age 61 years, IQR 48–69); 331 (86%) received solid organ transplantation and 54 (14%) had a RMD. CNIs were the only immunosuppressant administered in 47 patients (12%). We identified 14 (4%) COVID-19 patients, all transplanted, mainly presenting with fever (86%) and diarrhea (71%). Twelve patients were hospitalized and two of them died, both with severe comorbidities. No patients developed acute respiratory distress syndrome or infectious complications. The surviving 10 patients are now fully recovered. The clinical course of COVID-19 patients on CNIs is generally mild, and the risk of superinfection seems low. MDPI 2020-06-30 /pmc/articles/PMC7409165/ /pubmed/32629788 http://dx.doi.org/10.3390/microorganisms8070977 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Cavagna, Lorenzo
Seminari, Elena
Zanframundo, Giovanni
Gregorini, Marilena
Di Matteo, Angela
Rampino, Teresa
Montecucco, Carlomaurizio
Pelenghi, Stefano
Cattadori, Barbara
Pattonieri, Eleonora Francesca
Vitulo, Patrizio
Bertani, Alessandro
Sambataro, Gianluca
Vancheri, Carlo
Biglia, Alessandro
Bozzalla-Cassione, Emanuele
Bonetto, Valentina
Monti, Maria Cristina
Ticozzelli, Elena
Turco, Annalisa
Oggionni, Tiberio
Corsico, Angelo
Bertuccio, Francesco
Zuccaro, Valentina
Codullo, Veronica
Morosini, Monica
Marena, Carlo
Gnecchi, Massimiliano
Pellegrini, Carlo
Meloni, Federica
Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title_full Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title_fullStr Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title_full_unstemmed Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title_short Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
title_sort calcineurin inhibitor-based immunosuppression and covid-19: results from a multidisciplinary cohort of patients in northern italy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409165/
https://www.ncbi.nlm.nih.gov/pubmed/32629788
http://dx.doi.org/10.3390/microorganisms8070977
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