Cargando…

Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma

Due to chemoresistance and a high propensity to form lung metastasis, survival rates in pediatric osteosarcoma (OS) are poor. With the aim to improve anticancer activity in pediatric OS, a multidrug nanomedicine was designed using the alkyl-lysophospholipid edelfosine (EF) co-assembled with squaleno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Nogales, Carlos, Moreno, Haritz, Zandueta, Carolina, Desmaële, Didier, Lecanda, Fernando, Couvreur, Patrick, Blanco-Prieto, María J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409287/ https://www.ncbi.nlm.nih.gov/pubmed/32674353 http://dx.doi.org/10.3390/cancers12071895

Ejemplares similares

Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors
por: Rodríguez‐Nogales, Carlos, et al.
Publicado: (2021)

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines
por: Buchy, Eric, et al.
Publicado: (2016)

A Scalable Method for Squalenoylation and Assembly of Multifunctional (64)Cu-Labeled Squalenoylated Gemcitabine Nanoparticles
por: Tucci, Samantha T., et al.
Publicado: (2018)

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy
por: Maksimenko, Andrei, et al.
Publicado: (2014)

Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines
por: Valdez, B C, et al.
Publicado: (2014)

Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis
por: Gaudin, Alice, et al.
Publicado: (2015)

Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury
por: Gaudin, Alice, et al.
Publicado: (2014)

Self-assembled squalenoyl-cytarabine nanostructures as a potent nanomedicine for treatment of leukemic diseases
por: Cosco, Donato, et al.
Publicado: (2012)

Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A
por: Boutary, Suzan, et al.
Publicado: (2021)

Doxorubicin and Edelfosine Combo-Loaded Lipid–Polymer Hybrid Nanoparticles for Synergistic Anticancer Effect Against Drug-Resistant Osteosarcoma
por: Yang, Ping, et al.
Publicado: (2020)

In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
por: Yepes, Edward, et al.
Publicado: (2014)

Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine
por: Bonilla, Ximena, et al.
Publicado: (2015)

EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth
por: Perurena, Naiara, et al.
Publicado: (2017)

Correction: In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
Publicado: (2015)

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel
por: Yepes, Edward, et al.
Publicado: (2015)

Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1
por: Weekes, Daniel, et al.
Publicado: (2015)

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
por: Sobot, Dunja, et al.
Publicado: (2017)

Advanced nanomedicines for the treatment of inflammatory diseases
por: Brusini, Romain, et al.
Publicado: (2020)

Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria
por: Mollinedo, F, et al.
Publicado: (2011)

Polymeric Core–Shell Combinatorial Nanomedicine for Synergistic Anticancer Therapy
por: Shanavas, Asifkhan, et al.
Publicado: (2019)

Power in Numbers: Harnessing Combinatorial and Integrated Screens to Advance Nanomedicine
por: Boehnke, Natalie, et al.
Publicado: (2021)

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis
por: Selivanov, Vitaly A, et al.
Publicado: (2010)

Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model
por: Saraiva, Sofia M., et al.
Publicado: (2021)

In Vitro and In Vivo Efficacy of Ether Lipid Edelfosine against Leishmania spp. and SbV-Resistant Parasites
por: Varela-M, Rubén E., et al.
Publicado: (2012)

Lipid-Conjugation of Endogenous Neuropeptides: Improved Biotherapy against Human Pancreatic Cancer
por: Gopalakrishnan, Gopakumar, et al.
Publicado: (2015)

The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models
por: Martín-Fernández, Marta, et al.
Publicado: (2017)

Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer
por: Liu, Peng, et al.
Publicado: (2022)

Bioorthogonal CRISPR/Cas9‐Drug Conjugate: A Combinatorial Nanomedicine Platform
por: Beha, Marcel Janis, et al.
Publicado: (2023)

Sphere-derived tumor cells exhibit impaired metastasis by a host-mediated quiescent phenotype
por: Bleau, Anne-Marie, et al.
Publicado: (2015)

Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma
por: Nguyen, Tuyen Duong Thanh, et al.
Publicado: (2016)

Introduction to Nanomedicine
por: Astruc, Didier
Publicado: (2015)

The Orally Available, Synthetic Ether Lipid Edelfosine Inhibits T Cell Proliferation and Induces a Type I Interferon Response
por: Abramowski, Pierre, et al.
Publicado: (2014)

Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine
por: Mollinedo, Faustino, et al.
Publicado: (2021)

Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel
por: Vágvölgyi, Máté, et al.
Publicado: (2020)

4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
por: Torresan, Veronica, et al.
Publicado: (2020)

Combinatorial synthesis and screening of cancer cell-specific nanomedicines targeted via phage fusion proteins
por: Gillespie, James W., et al.
Publicado: (2015)

A Tumor-Activatable Theranostic Nanomedicine Platform for NIR Fluorescence-Guided Surgery and Combinatorial Phototherapy
por: Li, Xiaoning, et al.
Publicado: (2018)

Involvement of Raft Aggregates Enriched in Fas/CD95 Death-Inducing Signaling Complex in the Antileukemic Action of Edelfosine in Jurkat Cells
por: Gajate, Consuelo, et al.
Publicado: (2009)

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer
por: Mollinedo, Faustino, et al.
Publicado: (2021)

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition
por: Gajate, Consuelo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bpf162jn17vaqfs00aods40uv7