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Non-Conventional Treatments for Conventional Chondrosarcoma
Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; howe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409290/ https://www.ncbi.nlm.nih.gov/pubmed/32707689 http://dx.doi.org/10.3390/cancers12071962 |
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author | Monga, Varun Mani, Hariharasudan Hirbe, Angela Milhem, Mohammed |
author_facet | Monga, Varun Mani, Hariharasudan Hirbe, Angela Milhem, Mohammed |
author_sort | Monga, Varun |
collection | PubMed |
description | Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma. |
format | Online Article Text |
id | pubmed-7409290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74092902020-08-25 Non-Conventional Treatments for Conventional Chondrosarcoma Monga, Varun Mani, Hariharasudan Hirbe, Angela Milhem, Mohammed Cancers (Basel) Review Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma. MDPI 2020-07-19 /pmc/articles/PMC7409290/ /pubmed/32707689 http://dx.doi.org/10.3390/cancers12071962 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Monga, Varun Mani, Hariharasudan Hirbe, Angela Milhem, Mohammed Non-Conventional Treatments for Conventional Chondrosarcoma |
title | Non-Conventional Treatments for Conventional Chondrosarcoma |
title_full | Non-Conventional Treatments for Conventional Chondrosarcoma |
title_fullStr | Non-Conventional Treatments for Conventional Chondrosarcoma |
title_full_unstemmed | Non-Conventional Treatments for Conventional Chondrosarcoma |
title_short | Non-Conventional Treatments for Conventional Chondrosarcoma |
title_sort | non-conventional treatments for conventional chondrosarcoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409290/ https://www.ncbi.nlm.nih.gov/pubmed/32707689 http://dx.doi.org/10.3390/cancers12071962 |
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