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Non-Conventional Treatments for Conventional Chondrosarcoma

Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; howe...

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Detalles Bibliográficos
Autores principales: Monga, Varun, Mani, Hariharasudan, Hirbe, Angela, Milhem, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409290/
https://www.ncbi.nlm.nih.gov/pubmed/32707689
http://dx.doi.org/10.3390/cancers12071962
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author Monga, Varun
Mani, Hariharasudan
Hirbe, Angela
Milhem, Mohammed
author_facet Monga, Varun
Mani, Hariharasudan
Hirbe, Angela
Milhem, Mohammed
author_sort Monga, Varun
collection PubMed
description Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma.
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spelling pubmed-74092902020-08-25 Non-Conventional Treatments for Conventional Chondrosarcoma Monga, Varun Mani, Hariharasudan Hirbe, Angela Milhem, Mohammed Cancers (Basel) Review Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma. MDPI 2020-07-19 /pmc/articles/PMC7409290/ /pubmed/32707689 http://dx.doi.org/10.3390/cancers12071962 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Monga, Varun
Mani, Hariharasudan
Hirbe, Angela
Milhem, Mohammed
Non-Conventional Treatments for Conventional Chondrosarcoma
title Non-Conventional Treatments for Conventional Chondrosarcoma
title_full Non-Conventional Treatments for Conventional Chondrosarcoma
title_fullStr Non-Conventional Treatments for Conventional Chondrosarcoma
title_full_unstemmed Non-Conventional Treatments for Conventional Chondrosarcoma
title_short Non-Conventional Treatments for Conventional Chondrosarcoma
title_sort non-conventional treatments for conventional chondrosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409290/
https://www.ncbi.nlm.nih.gov/pubmed/32707689
http://dx.doi.org/10.3390/cancers12071962
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