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Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas

This study aimed to assess how to enhance the value of (18)F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, (18)F-FDG-PET images were obtained after fasting and after glucose loadi...

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Autores principales: Kim, Dongwoo, Ko, Hae Young, Lee, Sangwon, Lee, Yong-ho, Ryu, Sujin, Kim, Seon Yoo, Chung, Jee-in, Lee, Misu, Moon, Ju Hyung, Chang, Jong Hee, Yun, Mijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409292/
https://www.ncbi.nlm.nih.gov/pubmed/32698507
http://dx.doi.org/10.3390/cancers12071977
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author Kim, Dongwoo
Ko, Hae Young
Lee, Sangwon
Lee, Yong-ho
Ryu, Sujin
Kim, Seon Yoo
Chung, Jee-in
Lee, Misu
Moon, Ju Hyung
Chang, Jong Hee
Yun, Mijin
author_facet Kim, Dongwoo
Ko, Hae Young
Lee, Sangwon
Lee, Yong-ho
Ryu, Sujin
Kim, Seon Yoo
Chung, Jee-in
Lee, Misu
Moon, Ju Hyung
Chang, Jong Hee
Yun, Mijin
author_sort Kim, Dongwoo
collection PubMed
description This study aimed to assess how to enhance the value of (18)F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, (18)F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. (14)C-2-Deoxy-D-glucose ((14)C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuron ratio of (14)C-DG uptake increased with up to 10 mM of glucose. Finally, 10 low-grade and 17 high-grade glioma patients underwent fasting and glucose loading (18)F-FDG PET/CT and the TNR was compared between scans. The effect of glucose loading was significant in high-grade but not in low-grade gliomas. The receiver operating characteristic curve analyses with a cut-off TNR of 0.81 showed a higher area under the curve after glucose loading than fasting for differentiating low-grade versus high-grade gliomas. In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in (18)F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of (18)F-FDG PET/CT for grading.
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spelling pubmed-74092922020-08-25 Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas Kim, Dongwoo Ko, Hae Young Lee, Sangwon Lee, Yong-ho Ryu, Sujin Kim, Seon Yoo Chung, Jee-in Lee, Misu Moon, Ju Hyung Chang, Jong Hee Yun, Mijin Cancers (Basel) Article This study aimed to assess how to enhance the value of (18)F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, (18)F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. (14)C-2-Deoxy-D-glucose ((14)C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuron ratio of (14)C-DG uptake increased with up to 10 mM of glucose. Finally, 10 low-grade and 17 high-grade glioma patients underwent fasting and glucose loading (18)F-FDG PET/CT and the TNR was compared between scans. The effect of glucose loading was significant in high-grade but not in low-grade gliomas. The receiver operating characteristic curve analyses with a cut-off TNR of 0.81 showed a higher area under the curve after glucose loading than fasting for differentiating low-grade versus high-grade gliomas. In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in (18)F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of (18)F-FDG PET/CT for grading. MDPI 2020-07-20 /pmc/articles/PMC7409292/ /pubmed/32698507 http://dx.doi.org/10.3390/cancers12071977 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Dongwoo
Ko, Hae Young
Lee, Sangwon
Lee, Yong-ho
Ryu, Sujin
Kim, Seon Yoo
Chung, Jee-in
Lee, Misu
Moon, Ju Hyung
Chang, Jong Hee
Yun, Mijin
Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title_full Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title_fullStr Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title_full_unstemmed Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title_short Glucose Loading Enhances the Value of (18)F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas
title_sort glucose loading enhances the value of (18)f-fdg pet/ct for the characterization and delineation of cerebral gliomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409292/
https://www.ncbi.nlm.nih.gov/pubmed/32698507
http://dx.doi.org/10.3390/cancers12071977
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