KLF4 Coordinates Corneal Epithelial Apical-Basal Polarity and Plane of Cell Division and Is Downregulated in Ocular Surface Squamous Neoplasia

PURPOSE: Previously, we demonstrated that Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) homeostasis by suppressing epithelial-mesenchymal transition (EMT) and TGF-β signaling. As TGF-β affects epithelial apicobasal polarity (ABP) and plane of division, we investigated the role of KLF...

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Detalles Bibliográficos
Autores principales: Tiwari, Anil, Swamynathan, Sudha, Jhanji, Vishal, Swamynathan, Shivalingappa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409308/
https://www.ncbi.nlm.nih.gov/pubmed/32396634
http://dx.doi.org/10.1167/iovs.61.5.15

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