Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer

Breast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treat...

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Autores principales: Lu, Chengli, Ma, Zhiyuan, Cheng, Xiaoming, Wu, Huichao, Tuo, Biguang, Liu, Xuemei, Li, Taolang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409684/
https://www.ncbi.nlm.nih.gov/pubmed/32782435
http://dx.doi.org/10.1186/s12935-020-01464-9
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author Lu, Chengli
Ma, Zhiyuan
Cheng, Xiaoming
Wu, Huichao
Tuo, Biguang
Liu, Xuemei
Li, Taolang
author_facet Lu, Chengli
Ma, Zhiyuan
Cheng, Xiaoming
Wu, Huichao
Tuo, Biguang
Liu, Xuemei
Li, Taolang
author_sort Lu, Chengli
collection PubMed
description Breast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treatments are surgery and chemotherapy; no targeted standard treatment options are available. Therefore, it is urgent to find a novel and effective therapeutic target. As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC and may provide new tumor biomarkers and help in the development of novel targeted therapies.
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spelling pubmed-74096842020-08-10 Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer Lu, Chengli Ma, Zhiyuan Cheng, Xiaoming Wu, Huichao Tuo, Biguang Liu, Xuemei Li, Taolang Cancer Cell Int Review Breast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treatments are surgery and chemotherapy; no targeted standard treatment options are available. Therefore, it is urgent to find a novel and effective therapeutic target. As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC and may provide new tumor biomarkers and help in the development of novel targeted therapies. BioMed Central 2020-08-06 /pmc/articles/PMC7409684/ /pubmed/32782435 http://dx.doi.org/10.1186/s12935-020-01464-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Chengli
Ma, Zhiyuan
Cheng, Xiaoming
Wu, Huichao
Tuo, Biguang
Liu, Xuemei
Li, Taolang
Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title_full Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title_fullStr Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title_full_unstemmed Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title_short Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
title_sort pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409684/
https://www.ncbi.nlm.nih.gov/pubmed/32782435
http://dx.doi.org/10.1186/s12935-020-01464-9
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