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Asthma among hospitalized patients with COVID-19 and related outcomes

BACKGROUND: Several underlying conditions have been associated with severe acute respiratory syndrome coronavirus 2 illness, but it remains unclear whether underlying asthma is associated with worse coronavirus disease 2019 (COVID-19) outcomes. OBJECTIVE: Given the high prevalence of asthma in the N...

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Autores principales: Lovinsky-Desir, Stephanie, Deshpande, Deepti R., De, Aliva, Murray, Laurie, Stingone, Jeanette A., Chan, Angela, Patel, Neha, Rai, Nooralam, DiMango, Emily, Milner, Joshua, Kattan, Meyer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409831/
https://www.ncbi.nlm.nih.gov/pubmed/32771560
http://dx.doi.org/10.1016/j.jaci.2020.07.026
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author Lovinsky-Desir, Stephanie
Deshpande, Deepti R.
De, Aliva
Murray, Laurie
Stingone, Jeanette A.
Chan, Angela
Patel, Neha
Rai, Nooralam
DiMango, Emily
Milner, Joshua
Kattan, Meyer
author_facet Lovinsky-Desir, Stephanie
Deshpande, Deepti R.
De, Aliva
Murray, Laurie
Stingone, Jeanette A.
Chan, Angela
Patel, Neha
Rai, Nooralam
DiMango, Emily
Milner, Joshua
Kattan, Meyer
author_sort Lovinsky-Desir, Stephanie
collection PubMed
description BACKGROUND: Several underlying conditions have been associated with severe acute respiratory syndrome coronavirus 2 illness, but it remains unclear whether underlying asthma is associated with worse coronavirus disease 2019 (COVID-19) outcomes. OBJECTIVE: Given the high prevalence of asthma in the New York City area, our objective was to determine whether underlying asthma was associated with poor outcomes among hospitalized patients with severe COVID-19 compared with patients without asthma. METHODS: Electronic heath records were reviewed for 1298 sequential patients 65 years or younger without chronic obstructive pulmonary disease who were admitted to our hospital system with a confirmed positive severe acute respiratory syndrome coronavirus 2 test result. RESULTS: The overall prevalence of asthma among all hospitalized patients with COVID-19 was 12.6%, yet a higher prevalence (23.6%) was observed in the subset of 55 patients younger than 21 years. There was no significant difference in hospital length of stay, need for intubation, length of intubation, tracheostomy tube placement, hospital readmission, or mortality between patients with and without asthma. Observations between patients with and without asthma were similar when stratified by obesity, other comorbid conditions (ie, hypertension, hyperlipidemia, and diabetes), use of controller asthma medication, and absolute eosinophil count. CONCLUSIONS: Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies are needed to investigate the risk of developing COVID-19 among patients with asthma once universal testing becomes readily available.
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spelling pubmed-74098312020-08-07 Asthma among hospitalized patients with COVID-19 and related outcomes Lovinsky-Desir, Stephanie Deshpande, Deepti R. De, Aliva Murray, Laurie Stingone, Jeanette A. Chan, Angela Patel, Neha Rai, Nooralam DiMango, Emily Milner, Joshua Kattan, Meyer J Allergy Clin Immunol Asthma and Lower Airway Disease BACKGROUND: Several underlying conditions have been associated with severe acute respiratory syndrome coronavirus 2 illness, but it remains unclear whether underlying asthma is associated with worse coronavirus disease 2019 (COVID-19) outcomes. OBJECTIVE: Given the high prevalence of asthma in the New York City area, our objective was to determine whether underlying asthma was associated with poor outcomes among hospitalized patients with severe COVID-19 compared with patients without asthma. METHODS: Electronic heath records were reviewed for 1298 sequential patients 65 years or younger without chronic obstructive pulmonary disease who were admitted to our hospital system with a confirmed positive severe acute respiratory syndrome coronavirus 2 test result. RESULTS: The overall prevalence of asthma among all hospitalized patients with COVID-19 was 12.6%, yet a higher prevalence (23.6%) was observed in the subset of 55 patients younger than 21 years. There was no significant difference in hospital length of stay, need for intubation, length of intubation, tracheostomy tube placement, hospital readmission, or mortality between patients with and without asthma. Observations between patients with and without asthma were similar when stratified by obesity, other comorbid conditions (ie, hypertension, hyperlipidemia, and diabetes), use of controller asthma medication, and absolute eosinophil count. CONCLUSIONS: Among hospitalized patients 65 years or younger with severe COVID-19, asthma diagnosis was not associated with worse outcomes, regardless of age, obesity, or other high-risk comorbidities. Future population-based studies are needed to investigate the risk of developing COVID-19 among patients with asthma once universal testing becomes readily available. American Academy of Allergy, Asthma & Immunology 2020-11 2020-08-06 /pmc/articles/PMC7409831/ /pubmed/32771560 http://dx.doi.org/10.1016/j.jaci.2020.07.026 Text en © 2020 American Academy of Allergy, Asthma & Immunology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Asthma and Lower Airway Disease
Lovinsky-Desir, Stephanie
Deshpande, Deepti R.
De, Aliva
Murray, Laurie
Stingone, Jeanette A.
Chan, Angela
Patel, Neha
Rai, Nooralam
DiMango, Emily
Milner, Joshua
Kattan, Meyer
Asthma among hospitalized patients with COVID-19 and related outcomes
title Asthma among hospitalized patients with COVID-19 and related outcomes
title_full Asthma among hospitalized patients with COVID-19 and related outcomes
title_fullStr Asthma among hospitalized patients with COVID-19 and related outcomes
title_full_unstemmed Asthma among hospitalized patients with COVID-19 and related outcomes
title_short Asthma among hospitalized patients with COVID-19 and related outcomes
title_sort asthma among hospitalized patients with covid-19 and related outcomes
topic Asthma and Lower Airway Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409831/
https://www.ncbi.nlm.nih.gov/pubmed/32771560
http://dx.doi.org/10.1016/j.jaci.2020.07.026
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