Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Diabetes, obesity, and Alzheimer’s disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein–cleaving (APP-cleaving) enzyme 1 (BACE1), APP, and β-amyloid (Aβ) are linked with vascular disease development...

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Detalles Bibliográficos
Autores principales: Meakin, Paul J., Coull, Bethany M., Tuharska, Zofia, McCaffery, Christopher, Akoumianakis, Ioannis, Antoniades, Charalambos, Brown, Jane, Griffin, Kathryn J., Platt, Fiona, Ozber, Claire H., Yuldasheva, Nadira Y., Makava, Natallia, Skromna, Anna, Prescott, Alan, McNeilly, Alison D., Siddiqui, Moneeza, Palmer, Colin N.A., Khan, Faisel, Ashford, Michael L.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410081/
https://www.ncbi.nlm.nih.gov/pubmed/32407295
http://dx.doi.org/10.1172/JCI122237

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