Cancer Treatment: An Epigenetic View

Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the e...

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Detalles Bibliográficos
Autores principales: Aydin, Cansu, Kalkan, Rasime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410103/
https://www.ncbi.nlm.nih.gov/pubmed/32879917
http://dx.doi.org/10.1055/s-0040-1713610
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author Aydin, Cansu
Kalkan, Rasime
author_facet Aydin, Cansu
Kalkan, Rasime
author_sort Aydin, Cansu
collection PubMed
description Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics.
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spelling pubmed-74101032020-09-01 Cancer Treatment: An Epigenetic View Aydin, Cansu Kalkan, Rasime Glob Med Genet Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics. Georg Thieme Verlag KG 2020-06 2020-07-15 /pmc/articles/PMC7410103/ /pubmed/32879917 http://dx.doi.org/10.1055/s-0040-1713610 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Aydin, Cansu
Kalkan, Rasime
Cancer Treatment: An Epigenetic View
title Cancer Treatment: An Epigenetic View
title_full Cancer Treatment: An Epigenetic View
title_fullStr Cancer Treatment: An Epigenetic View
title_full_unstemmed Cancer Treatment: An Epigenetic View
title_short Cancer Treatment: An Epigenetic View
title_sort cancer treatment: an epigenetic view
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410103/
https://www.ncbi.nlm.nih.gov/pubmed/32879917
http://dx.doi.org/10.1055/s-0040-1713610
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