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Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?

BACKGROUND: Chickenpox is a highly contagious airborne disease caused by the varicella zoster virus. It is generally benign and self-limiting, but it may be responsible of life-threatening complications. Acute cerebellitis (AC) is the most common neurological complication and is associated with prol...

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Autores principales: Bozzola, Elena, Guolo, Stefano, Macchiarulo, Giulia, Festa, Lidia, Spina, Giulia, Krzysztofiak, Andrzej, Grandin, Annalisa, Bozzola, Mauro, Raponi, Massimiliano, Villani, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410155/
https://www.ncbi.nlm.nih.gov/pubmed/32762761
http://dx.doi.org/10.1186/s13052-020-00875-8
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author Bozzola, Elena
Guolo, Stefano
Macchiarulo, Giulia
Festa, Lidia
Spina, Giulia
Krzysztofiak, Andrzej
Grandin, Annalisa
Bozzola, Mauro
Raponi, Massimiliano
Villani, Alberto
author_facet Bozzola, Elena
Guolo, Stefano
Macchiarulo, Giulia
Festa, Lidia
Spina, Giulia
Krzysztofiak, Andrzej
Grandin, Annalisa
Bozzola, Mauro
Raponi, Massimiliano
Villani, Alberto
author_sort Bozzola, Elena
collection PubMed
description BACKGROUND: Chickenpox is a highly contagious airborne disease caused by the varicella zoster virus. It is generally benign and self-limiting, but it may be responsible of life-threatening complications. Acute cerebellitis (AC) is the most common neurological complication and is associated with prolonged hospitalization in the acute phase (HAP). AIM OF THE STUDY: To estimate the costs of AC HAP in children affected by varicella. MATERIALS AND METHODS: We retrospectively reviewed the medical records of a pediatric cohort hospitalized for chickenpox AC over a period of 15 years (from October 2003 to October 2018) and we analyzed acute care costs. For any patient the HAP has been calculated. The final value includes cost of hospital accommodation and management at the Pediatric and Infectious Diseases Unit. To this cost, the price of procedures (imaging, laboratory exams, medical and paramedical evaluations) and medical treatments was added. RESULTS: In the study period, 856 children had been hospitalized for varicella. Out of them, 65 met a diagnosis of AC and were included in the study. The hospitalization length was of 10 days (range 3–20 days). The median cost of HAP for each patient was of 5366 euro, with an average annual cost of 23,252 €. The most significant part of HAP is due to the cost of hospital accommodation and management at the Pediatric Infectious Diseases Unit, which was about € 537.78 for a single day. DISCUSSION: Although AC post-varicella is rare, its HAP cost is not negligible resulting in substantial economic burden. Vaccination would have probably prevented varicella and AC complication, avoiding hospitalization. CONCLUSIONS: Financial studies are important for evaluate the cost saving in order to influence public funding decisions. Further studies are necessary to investigate the economic burden of the disease.
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spelling pubmed-74101552020-08-10 Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost? Bozzola, Elena Guolo, Stefano Macchiarulo, Giulia Festa, Lidia Spina, Giulia Krzysztofiak, Andrzej Grandin, Annalisa Bozzola, Mauro Raponi, Massimiliano Villani, Alberto Ital J Pediatr Research BACKGROUND: Chickenpox is a highly contagious airborne disease caused by the varicella zoster virus. It is generally benign and self-limiting, but it may be responsible of life-threatening complications. Acute cerebellitis (AC) is the most common neurological complication and is associated with prolonged hospitalization in the acute phase (HAP). AIM OF THE STUDY: To estimate the costs of AC HAP in children affected by varicella. MATERIALS AND METHODS: We retrospectively reviewed the medical records of a pediatric cohort hospitalized for chickenpox AC over a period of 15 years (from October 2003 to October 2018) and we analyzed acute care costs. For any patient the HAP has been calculated. The final value includes cost of hospital accommodation and management at the Pediatric and Infectious Diseases Unit. To this cost, the price of procedures (imaging, laboratory exams, medical and paramedical evaluations) and medical treatments was added. RESULTS: In the study period, 856 children had been hospitalized for varicella. Out of them, 65 met a diagnosis of AC and were included in the study. The hospitalization length was of 10 days (range 3–20 days). The median cost of HAP for each patient was of 5366 euro, with an average annual cost of 23,252 €. The most significant part of HAP is due to the cost of hospital accommodation and management at the Pediatric Infectious Diseases Unit, which was about € 537.78 for a single day. DISCUSSION: Although AC post-varicella is rare, its HAP cost is not negligible resulting in substantial economic burden. Vaccination would have probably prevented varicella and AC complication, avoiding hospitalization. CONCLUSIONS: Financial studies are important for evaluate the cost saving in order to influence public funding decisions. Further studies are necessary to investigate the economic burden of the disease. BioMed Central 2020-08-06 /pmc/articles/PMC7410155/ /pubmed/32762761 http://dx.doi.org/10.1186/s13052-020-00875-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bozzola, Elena
Guolo, Stefano
Macchiarulo, Giulia
Festa, Lidia
Spina, Giulia
Krzysztofiak, Andrzej
Grandin, Annalisa
Bozzola, Mauro
Raponi, Massimiliano
Villani, Alberto
Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title_full Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title_fullStr Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title_full_unstemmed Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title_short Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
title_sort hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410155/
https://www.ncbi.nlm.nih.gov/pubmed/32762761
http://dx.doi.org/10.1186/s13052-020-00875-8
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