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Association between obesity and miscarriage among women of reproductive age in Nepal

BACKGROUND: Obesity is a major health problem in low and middle income countries (LMICs) and is associated with miscarriage. This study aims to examine the association between obesity and miscarriage among reproductive age women (15–49 years) in Nepal. METHODS: The combined 19160 cross-sectional pre...

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Autores principales: Ghimire, Pramesh Raj, Akombi-Inyang, Blessing J., Tannous, Caterina, Agho, Kingsley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410243/
https://www.ncbi.nlm.nih.gov/pubmed/32760090
http://dx.doi.org/10.1371/journal.pone.0236435
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author Ghimire, Pramesh Raj
Akombi-Inyang, Blessing J.
Tannous, Caterina
Agho, Kingsley E.
author_facet Ghimire, Pramesh Raj
Akombi-Inyang, Blessing J.
Tannous, Caterina
Agho, Kingsley E.
author_sort Ghimire, Pramesh Raj
collection PubMed
description BACKGROUND: Obesity is a major health problem in low and middle income countries (LMICs) and is associated with miscarriage. This study aims to examine the association between obesity and miscarriage among reproductive age women (15–49 years) in Nepal. METHODS: The combined 19160 cross-sectional pregnancy data from the Nepal Demographic and Health Survey (NDHS) for the years 2001, 2006, 2011 and 2016 was utilized. Miscarriage was defined as a spontaneous loss of pregnancy that occurred before the foetus reached 7 months of gestational age. Logistic regression analyses that adjusted for clustering, stratification and sampling weights were used to examine the association between obesity and miscarriage among women of reproductive age. RESULTS: The odds of miscarriage were 1.45 times higher (Adjusted odds ratio (AOR) =  1.45; 95%Cl: 1.06, 1.98, P = 0.021) among women with obesity. Women who did not use contraception, younger (15–19 years), and older women (35 years or more) were significantly more likely to have miscarriage. Women who smoked tobacco reported higher odds of miscarriage than women who did not smoke tobacco (AOR =  1.27; 95%Cl: 1.07,1.50, P = 0.006). Stratification of maternal smoking status by maternal Body Mass Index (BMI), after adjusting for contraception, mother age and year of survey revealed that tobacco smoking and obesity are associated with miscarriage (AOR =  1.46; 95%Cl: 1.05,2.04, P = 0.025). CONCLUSIONS: Findings from this study show that obesity and tobacco smoking are associated with miscarriage. Smoking cessation, pregnancy planning and counselling on healthy weight for women of reproductive age in Nepal may help promote healthy behaviours and decrease the likelihood of miscarriage.
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spelling pubmed-74102432020-08-13 Association between obesity and miscarriage among women of reproductive age in Nepal Ghimire, Pramesh Raj Akombi-Inyang, Blessing J. Tannous, Caterina Agho, Kingsley E. PLoS One Research Article BACKGROUND: Obesity is a major health problem in low and middle income countries (LMICs) and is associated with miscarriage. This study aims to examine the association between obesity and miscarriage among reproductive age women (15–49 years) in Nepal. METHODS: The combined 19160 cross-sectional pregnancy data from the Nepal Demographic and Health Survey (NDHS) for the years 2001, 2006, 2011 and 2016 was utilized. Miscarriage was defined as a spontaneous loss of pregnancy that occurred before the foetus reached 7 months of gestational age. Logistic regression analyses that adjusted for clustering, stratification and sampling weights were used to examine the association between obesity and miscarriage among women of reproductive age. RESULTS: The odds of miscarriage were 1.45 times higher (Adjusted odds ratio (AOR) =  1.45; 95%Cl: 1.06, 1.98, P = 0.021) among women with obesity. Women who did not use contraception, younger (15–19 years), and older women (35 years or more) were significantly more likely to have miscarriage. Women who smoked tobacco reported higher odds of miscarriage than women who did not smoke tobacco (AOR =  1.27; 95%Cl: 1.07,1.50, P = 0.006). Stratification of maternal smoking status by maternal Body Mass Index (BMI), after adjusting for contraception, mother age and year of survey revealed that tobacco smoking and obesity are associated with miscarriage (AOR =  1.46; 95%Cl: 1.05,2.04, P = 0.025). CONCLUSIONS: Findings from this study show that obesity and tobacco smoking are associated with miscarriage. Smoking cessation, pregnancy planning and counselling on healthy weight for women of reproductive age in Nepal may help promote healthy behaviours and decrease the likelihood of miscarriage. Public Library of Science 2020-08-06 /pmc/articles/PMC7410243/ /pubmed/32760090 http://dx.doi.org/10.1371/journal.pone.0236435 Text en © 2020 Ghimire et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ghimire, Pramesh Raj
Akombi-Inyang, Blessing J.
Tannous, Caterina
Agho, Kingsley E.
Association between obesity and miscarriage among women of reproductive age in Nepal
title Association between obesity and miscarriage among women of reproductive age in Nepal
title_full Association between obesity and miscarriage among women of reproductive age in Nepal
title_fullStr Association between obesity and miscarriage among women of reproductive age in Nepal
title_full_unstemmed Association between obesity and miscarriage among women of reproductive age in Nepal
title_short Association between obesity and miscarriage among women of reproductive age in Nepal
title_sort association between obesity and miscarriage among women of reproductive age in nepal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410243/
https://www.ncbi.nlm.nih.gov/pubmed/32760090
http://dx.doi.org/10.1371/journal.pone.0236435
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