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Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study

OBJECTIVE: Female sex, body mass index (BMI), and neuromuscular blocking agents are risk factors of perioperative hypersensitivity reactions. This study aimed to investigate the effect of rocuronium on serum tryptase concentrations during general anesthesia in overweight and obese women. METHODS: Th...

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Autores principales: Kosciuczuk, Urszula, Knapp, Pawel, Jakubow, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Medicina / USP 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410359/
https://www.ncbi.nlm.nih.gov/pubmed/32785569
http://dx.doi.org/10.6061/clinics/2020/e1701
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author Kosciuczuk, Urszula
Knapp, Pawel
Jakubow, Piotr
author_facet Kosciuczuk, Urszula
Knapp, Pawel
Jakubow, Piotr
author_sort Kosciuczuk, Urszula
collection PubMed
description OBJECTIVE: Female sex, body mass index (BMI), and neuromuscular blocking agents are risk factors of perioperative hypersensitivity reactions. This study aimed to investigate the effect of rocuronium on serum tryptase concentrations during general anesthesia in overweight and obese women. METHODS: The study was conducted in two groups: Group I (n=66) underwent volatile anesthesia with rocuronium and group II (n=60) underwent volatile anesthesia without any muscle relaxant. Serum tryptase concentration (STC) measurements were performed at baseline (STC 0) and postoperatively (STC 1). ClinicalTrials.gov: NCT04035707 RESULTS: The highest median value of STC 0 was seen in obese patients (3.44 μg L(-1)) and it was significantly higher than in overweight (p=0.01) and underweight patients (p=0.03). The maximum STC 0 was observed in overweight patients (20.4 μg L(-1)). In group I, STC 0 in obese patients presented the highest median value (4.49 μg L(-1)), and was significantly higher than in overweight patients (p=0.03), and had significantly higher STC 1 than patients with normal BMI (p=0.04). STC 0 and STC 1 in overweight and obese female patients did not differ significantly between groups. STC 1 did not correlate with rocuronium doses. In group I, BMI positively correlated with the duration of rocuronium infusion (rho=0.37) and STC 1 positively correlated with BMI (rho=0.32). CONCLUSION: Excess weight and obesity predispose to higher preoperative serum tryptase values. Postoperative STC is not linked to rocuronium doses. BMI is the main determinant factor of STC during combined volatile general anesthesia.
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spelling pubmed-74103592020-08-25 Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study Kosciuczuk, Urszula Knapp, Pawel Jakubow, Piotr Clinics (Sao Paulo) Original Article OBJECTIVE: Female sex, body mass index (BMI), and neuromuscular blocking agents are risk factors of perioperative hypersensitivity reactions. This study aimed to investigate the effect of rocuronium on serum tryptase concentrations during general anesthesia in overweight and obese women. METHODS: The study was conducted in two groups: Group I (n=66) underwent volatile anesthesia with rocuronium and group II (n=60) underwent volatile anesthesia without any muscle relaxant. Serum tryptase concentration (STC) measurements were performed at baseline (STC 0) and postoperatively (STC 1). ClinicalTrials.gov: NCT04035707 RESULTS: The highest median value of STC 0 was seen in obese patients (3.44 μg L(-1)) and it was significantly higher than in overweight (p=0.01) and underweight patients (p=0.03). The maximum STC 0 was observed in overweight patients (20.4 μg L(-1)). In group I, STC 0 in obese patients presented the highest median value (4.49 μg L(-1)), and was significantly higher than in overweight patients (p=0.03), and had significantly higher STC 1 than patients with normal BMI (p=0.04). STC 0 and STC 1 in overweight and obese female patients did not differ significantly between groups. STC 1 did not correlate with rocuronium doses. In group I, BMI positively correlated with the duration of rocuronium infusion (rho=0.37) and STC 1 positively correlated with BMI (rho=0.32). CONCLUSION: Excess weight and obesity predispose to higher preoperative serum tryptase values. Postoperative STC is not linked to rocuronium doses. BMI is the main determinant factor of STC during combined volatile general anesthesia. Faculdade de Medicina / USP 2020-08-06 2020 /pmc/articles/PMC7410359/ /pubmed/32785569 http://dx.doi.org/10.6061/clinics/2020/e1701 Text en Copyright © 2020 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Kosciuczuk, Urszula
Knapp, Pawel
Jakubow, Piotr
Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title_full Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title_fullStr Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title_full_unstemmed Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title_short Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
title_sort effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410359/
https://www.ncbi.nlm.nih.gov/pubmed/32785569
http://dx.doi.org/10.6061/clinics/2020/e1701
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