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Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?

Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of Plasmodium falciparum parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3...

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Autores principales: Beshir, Khalid B., Grignard, Lynn, Hajissa, Khalid, Mohammed, Abdulrahman, Nurhussein, Awolkhier M., Ishengoma, Deus S., Lubis, Inke Nadia D., Drakeley, Chris J., Sutherland, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410463/
https://www.ncbi.nlm.nih.gov/pubmed/32553046
http://dx.doi.org/10.4269/ajtmh.20-0467
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author Beshir, Khalid B.
Grignard, Lynn
Hajissa, Khalid
Mohammed, Abdulrahman
Nurhussein, Awolkhier M.
Ishengoma, Deus S.
Lubis, Inke Nadia D.
Drakeley, Chris J.
Sutherland, Colin J.
author_facet Beshir, Khalid B.
Grignard, Lynn
Hajissa, Khalid
Mohammed, Abdulrahman
Nurhussein, Awolkhier M.
Ishengoma, Deus S.
Lubis, Inke Nadia D.
Drakeley, Chris J.
Sutherland, Colin J.
author_sort Beshir, Khalid B.
collection PubMed
description Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of Plasmodium falciparum parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs. Surveillance of such parasites is dependent on identifying false-negative RDT results among suspected malaria cases, a task made more challenging during the current pandemic because of the overlap of symptoms between malaria and COVID-19, particularly in areas of low malaria transmission. Here, we share our perspective on the emergence of P. falciparum parasites lacking HRP2 and HRP3, and the surveillance needed to identify them amid the COVID-19 pandemic.
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spelling pubmed-74104632020-08-07 Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic? Beshir, Khalid B. Grignard, Lynn Hajissa, Khalid Mohammed, Abdulrahman Nurhussein, Awolkhier M. Ishengoma, Deus S. Lubis, Inke Nadia D. Drakeley, Chris J. Sutherland, Colin J. Am J Trop Med Hyg Perspective Piece Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. The emergence of Plasmodium falciparum parasites that can evade detection by RDTs threatens control and elimination efforts. These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs. Surveillance of such parasites is dependent on identifying false-negative RDT results among suspected malaria cases, a task made more challenging during the current pandemic because of the overlap of symptoms between malaria and COVID-19, particularly in areas of low malaria transmission. Here, we share our perspective on the emergence of P. falciparum parasites lacking HRP2 and HRP3, and the surveillance needed to identify them amid the COVID-19 pandemic. The American Society of Tropical Medicine and Hygiene 2020-08 2020-06-16 /pmc/articles/PMC7410463/ /pubmed/32553046 http://dx.doi.org/10.4269/ajtmh.20-0467 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective Piece
Beshir, Khalid B.
Grignard, Lynn
Hajissa, Khalid
Mohammed, Abdulrahman
Nurhussein, Awolkhier M.
Ishengoma, Deus S.
Lubis, Inke Nadia D.
Drakeley, Chris J.
Sutherland, Colin J.
Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title_full Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title_fullStr Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title_full_unstemmed Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title_short Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic?
title_sort emergence of undetectable malaria parasites: a threat under the radar amid the covid-19 pandemic?
topic Perspective Piece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410463/
https://www.ncbi.nlm.nih.gov/pubmed/32553046
http://dx.doi.org/10.4269/ajtmh.20-0467
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