The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 receptor, GFRAL, is located in a subset of cholecystokin...

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Detalles Bibliográficos
Autores principales: Worth, Amy A, Shoop, Rosemary, Tye, Katie, Feetham, Claire H, D'Agostino, Giuseppe, Dodd, Garron T, Reimann, Frank, Gribble, Fiona M, Beebe, Emily C, Dunbar, James D, Alexander-Chacko, Jesline T, Sindelar, Dana K, Coskun, Tamer, Emmerson, Paul J, Luckman, Simon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410488/
https://www.ncbi.nlm.nih.gov/pubmed/32723474
http://dx.doi.org/10.7554/eLife.55164

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