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Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds

Background  Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those...

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Autores principales: Kim, Paul J, Silverman, Ronald, Attinger, Christopher E, Griffin, Leah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410508/
https://www.ncbi.nlm.nih.gov/pubmed/32782866
http://dx.doi.org/10.7759/cureus.9047
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author Kim, Paul J
Silverman, Ronald
Attinger, Christopher E
Griffin, Leah
author_facet Kim, Paul J
Silverman, Ronald
Attinger, Christopher E
Griffin, Leah
author_sort Kim, Paul J
collection PubMed
description Background  Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline. Methods An analysis was performed using two previously published independent studies from a single investigator and hospital to compare patient characteristics and clinical outcomes of infected wounds from 74 NPWT-treated patients with 42 NPWTi-d-treated patients. Results  Patient demographics and comorbidities, wound etiologies, and anatomical locations of wounds were similar between groups, although a significantly higher percentage of NPWT-treated patients had end-stage renal disease (P = 0.0119). Compared with patients treated with standard NPWT, NPWTi-d-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001). Conclusions The results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT.
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spelling pubmed-74105082020-08-10 Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds Kim, Paul J Silverman, Ronald Attinger, Christopher E Griffin, Leah Cureus General Surgery Background  Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline. Methods An analysis was performed using two previously published independent studies from a single investigator and hospital to compare patient characteristics and clinical outcomes of infected wounds from 74 NPWT-treated patients with 42 NPWTi-d-treated patients. Results  Patient demographics and comorbidities, wound etiologies, and anatomical locations of wounds were similar between groups, although a significantly higher percentage of NPWT-treated patients had end-stage renal disease (P = 0.0119). Compared with patients treated with standard NPWT, NPWTi-d-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001). Conclusions The results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT. Cureus 2020-07-07 /pmc/articles/PMC7410508/ /pubmed/32782866 http://dx.doi.org/10.7759/cureus.9047 Text en Copyright © 2020, Kim et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle General Surgery
Kim, Paul J
Silverman, Ronald
Attinger, Christopher E
Griffin, Leah
Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title_full Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title_fullStr Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title_full_unstemmed Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title_short Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
title_sort comparison of negative pressure wound therapy with and without instillation of saline in the management of infected wounds
topic General Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410508/
https://www.ncbi.nlm.nih.gov/pubmed/32782866
http://dx.doi.org/10.7759/cureus.9047
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