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Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds
Background Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410508/ https://www.ncbi.nlm.nih.gov/pubmed/32782866 http://dx.doi.org/10.7759/cureus.9047 |
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author | Kim, Paul J Silverman, Ronald Attinger, Christopher E Griffin, Leah |
author_facet | Kim, Paul J Silverman, Ronald Attinger, Christopher E Griffin, Leah |
author_sort | Kim, Paul J |
collection | PubMed |
description | Background Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline. Methods An analysis was performed using two previously published independent studies from a single investigator and hospital to compare patient characteristics and clinical outcomes of infected wounds from 74 NPWT-treated patients with 42 NPWTi-d-treated patients. Results Patient demographics and comorbidities, wound etiologies, and anatomical locations of wounds were similar between groups, although a significantly higher percentage of NPWT-treated patients had end-stage renal disease (P = 0.0119). Compared with patients treated with standard NPWT, NPWTi-d-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001). Conclusions The results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT. |
format | Online Article Text |
id | pubmed-7410508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-74105082020-08-10 Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds Kim, Paul J Silverman, Ronald Attinger, Christopher E Griffin, Leah Cureus General Surgery Background Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d) includes periodic instillation of topical solution into the wound followed by a negative pressure. Our objective was to evaluate potential differences in wound outcomes in patients receiving NPWT and those receiving NPWTi-d using saline. Methods An analysis was performed using two previously published independent studies from a single investigator and hospital to compare patient characteristics and clinical outcomes of infected wounds from 74 NPWT-treated patients with 42 NPWTi-d-treated patients. Results Patient demographics and comorbidities, wound etiologies, and anatomical locations of wounds were similar between groups, although a significantly higher percentage of NPWT-treated patients had end-stage renal disease (P = 0.0119). Compared with patients treated with standard NPWT, NPWTi-d-treated patients had a significantly lower number of operations (P = 0.0048), shorter length of hospital stay (P = 0.0443), shorter time to final surgical procedure (P = 0.0001), higher percentage of closed wounds (P = 0.0004), and a higher percentage of wounds that remained closed at one month (P = 0.0001). Conclusions The results of this analysis suggest that management of infected wounds with NPWTi-d using saline leads to favorable wound outcomes when compared to those managed with NPWT. Cureus 2020-07-07 /pmc/articles/PMC7410508/ /pubmed/32782866 http://dx.doi.org/10.7759/cureus.9047 Text en Copyright © 2020, Kim et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | General Surgery Kim, Paul J Silverman, Ronald Attinger, Christopher E Griffin, Leah Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title | Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title_full | Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title_fullStr | Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title_full_unstemmed | Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title_short | Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds |
title_sort | comparison of negative pressure wound therapy with and without instillation of saline in the management of infected wounds |
topic | General Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410508/ https://www.ncbi.nlm.nih.gov/pubmed/32782866 http://dx.doi.org/10.7759/cureus.9047 |
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