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Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients

COVID-19 is a pandemic caused by human coronavirus (HCoV) SARS-CoV-2, which originated in Wuhan, China, at the end of 2019 and spread globally during 2020. Due to the difficulty of clinical decision-making during this period, our study group reviewed current literature focusing on the neurological a...

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Autores principales: Orsini, Alessandro, Corsi, Martina, Santangelo, Andrea, Riva, Antonella, Peroni, Diego, Foiadelli, Thomas, Savasta, Salvatore, Striano, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410516/
https://www.ncbi.nlm.nih.gov/pubmed/32767055
http://dx.doi.org/10.1007/s10072-020-04544-w
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author Orsini, Alessandro
Corsi, Martina
Santangelo, Andrea
Riva, Antonella
Peroni, Diego
Foiadelli, Thomas
Savasta, Salvatore
Striano, Pasquale
author_facet Orsini, Alessandro
Corsi, Martina
Santangelo, Andrea
Riva, Antonella
Peroni, Diego
Foiadelli, Thomas
Savasta, Salvatore
Striano, Pasquale
author_sort Orsini, Alessandro
collection PubMed
description COVID-19 is a pandemic caused by human coronavirus (HCoV) SARS-CoV-2, which originated in Wuhan, China, at the end of 2019 and spread globally during 2020. Due to the difficulty of clinical decision-making during this period, our study group reviewed current literature focusing on the neurological and psychiatric aspects of COVID-19. Despite the knowledge on this newly discovered virus which is constantly evolving, different pieces of evidence reported an association between COVID-19 and neurological symptoms like headache, dizziness, taste and smell disorders and complications involving the nervous system eventually triggered by the pathologic processes elicited by SARS-CoV-2. It seems that younger patients are less prone to develop severe forms of COVID-19. However, neurological signs have been reported in paediatric patients as well, and in some cases, the infection presented neurological sequelae. Furthermore, children with particular neurological diseases or treated with specific drugs (e.g. immune-suppressant therapies) must be carefully monitored during this pandemic. Neurologists should be aware of the main drug–drug interactions and the neurological side effects of COVID-19 treatments. Notably, adverse mental health impact has been reported in patients with SARS-CoV-2, which could be related either to the social strain or to the eventual neurotropic effects of the virus, which in other infections have been proven to promote the onset of psychiatric symptoms. Further, psychiatric population may be more vulnerable to the infection and at higher risk for adverse outcomes.
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spelling pubmed-74105162020-08-07 Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients Orsini, Alessandro Corsi, Martina Santangelo, Andrea Riva, Antonella Peroni, Diego Foiadelli, Thomas Savasta, Salvatore Striano, Pasquale Neurol Sci Covid-19 COVID-19 is a pandemic caused by human coronavirus (HCoV) SARS-CoV-2, which originated in Wuhan, China, at the end of 2019 and spread globally during 2020. Due to the difficulty of clinical decision-making during this period, our study group reviewed current literature focusing on the neurological and psychiatric aspects of COVID-19. Despite the knowledge on this newly discovered virus which is constantly evolving, different pieces of evidence reported an association between COVID-19 and neurological symptoms like headache, dizziness, taste and smell disorders and complications involving the nervous system eventually triggered by the pathologic processes elicited by SARS-CoV-2. It seems that younger patients are less prone to develop severe forms of COVID-19. However, neurological signs have been reported in paediatric patients as well, and in some cases, the infection presented neurological sequelae. Furthermore, children with particular neurological diseases or treated with specific drugs (e.g. immune-suppressant therapies) must be carefully monitored during this pandemic. Neurologists should be aware of the main drug–drug interactions and the neurological side effects of COVID-19 treatments. Notably, adverse mental health impact has been reported in patients with SARS-CoV-2, which could be related either to the social strain or to the eventual neurotropic effects of the virus, which in other infections have been proven to promote the onset of psychiatric symptoms. Further, psychiatric population may be more vulnerable to the infection and at higher risk for adverse outcomes. Springer International Publishing 2020-08-06 2020 /pmc/articles/PMC7410516/ /pubmed/32767055 http://dx.doi.org/10.1007/s10072-020-04544-w Text en © Fondazione Società Italiana di Neurologia 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Orsini, Alessandro
Corsi, Martina
Santangelo, Andrea
Riva, Antonella
Peroni, Diego
Foiadelli, Thomas
Savasta, Salvatore
Striano, Pasquale
Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title_full Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title_fullStr Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title_full_unstemmed Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title_short Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
title_sort challenges and management of neurological and psychiatric manifestations in sars-cov-2 (covid-19) patients
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410516/
https://www.ncbi.nlm.nih.gov/pubmed/32767055
http://dx.doi.org/10.1007/s10072-020-04544-w
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