Remdesivir and its antiviral activity against COVID-19: A systematic review

BACKGROUND: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. METHODS: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. RES...

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Detalles Bibliográficos
Autores principales: Frediansyah, Andri, Nainu, Firzan, Dhama, Kuldeep, Mudatsir, Mudatsir, Harapan, Harapan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier, a division of RELX India, Pvt. Ltd on behalf of INDIACLEN. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410793/
https://www.ncbi.nlm.nih.gov/pubmed/32838064
http://dx.doi.org/10.1016/j.cegh.2020.07.011
Descripción
Sumario:BACKGROUND: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. METHODS: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively. RESULTS: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients. CONCLUSION: Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.

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