Cargando…

The changing mouse embryo transcriptome at whole tissue and single-cell resolution

During mammalian embryogenesis, differential gene expression gradually builds the identity and complexity of each tissue and organ system(1). Here we systematically quantified mouse polyA-RNA from day 10.5 of embryonic development to birth, sampling 17 tissues and organs. The resulting developmental...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Peng, Williams, Brian A., Trout, Diane, Marinov, Georgi K., Amrhein, Henry, Berghella, Libera, Goh, Say-Tar, Plajzer-Frick, Ingrid, Afzal, Veena, Pennacchio, Len A., Dickel, Diane E., Visel, Axel, Ren, Bing, Hardison, Ross C., Zhang, Yu, Wold, Barbara J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410830/ https://www.ncbi.nlm.nih.gov/pubmed/32728245 http://dx.doi.org/10.1038/s41586-020-2536-x

Ejemplares similares

Function-based Identification of Mammalian Enhancers Using Site-Specific Integration
por: Dickel, Diane E., et al.
Publicado: (2014)

Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb
por: Monti, Remo, et al.
Publicado: (2017)

Enhancer Redundancy Allows for Phenotypic Robustness in Mammalian Development
por: Osterwalder, Marco, et al.
Publicado: (2018)

Genome-wide compendium and functional assessment of in vivo heart enhancers
por: Dickel, Diane E., et al.
Publicado: (2016)

Deletion of Ultraconserved Elements Yields Viable Mice
por: Ahituv, Nadav, et al.
Publicado: (2007)

Spatiotemporal DNA methylome dynamics of the developing mouse fetus
por: He, Yupeng, et al.
Publicado: (2020)

Supervised enhancer prediction with epigenetic pattern recognition and targeted validation
por: Sethi, Anurag, et al.
Publicado: (2020)

Genome-wide fetalization of enhancer architecture in heart disease
por: Spurrell, Cailyn H., et al.
Publicado: (2022)

Large-Scale Discovery of Enhancers from Human Heart Tissue
por: May, Dalit, et al.
Publicado: (2011)

Tissue-Specific RNA Expression Marks Distant-Acting Developmental Enhancers
por: Wu, Han, et al.
Publicado: (2014)

Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis
por: Attanasio, Catia, et al.
Publicado: (2014)

An atlas of dynamic chromatin landscapes in mouse fetal development
por: Gorkin, David U., et al.
Publicado: (2020)

Author Correction: An atlas of dynamic chromatin landscapes in mouse fetal development
por: Gorkin, David U., et al.
Publicado: (2020)

Author Correction: An atlas of dynamic chromatin landscapes in mouse fetal development
por: Gorkin, David U., et al.
Publicado: (2021)

Cell Type- and Tissue-specific Enhancers in Craniofacial Development
por: Rajderkar, Sudha Sunil, et al.
Publicado: (2023)

Genomic Views of Distant-Acting Enhancers
por: Visel, Axel, et al.
Publicado: (2009)

VISTA Enhancer Browser—a database of tissue-specific human enhancers
por: Visel, Axel, et al.
Publicado: (2007)

Topologically associating domain boundaries are required for normal genome function
por: Rajderkar, Sudha, et al.
Publicado: (2023)

Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
por: Lindtner, Susan, et al.
Publicado: (2019)

Targeted Deletion of the 9p21 Noncoding Coronary Artery Disease Risk Interval in Mice
por: Visel, Axel, et al.
Publicado: (2010)

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
por: Li, Shan, et al.
Publicado: (2019)

Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis
por: Catta-Preta, Rinaldo, et al.
Publicado: (2023)

Early Decrease in Respiration and Uncoupling Event Independent of Cytochrome c Release in PC12 Cells Undergoing Apoptosis
por: Berghella, Libera, et al.
Publicado: (2012)

Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression
por: Ariza-Cosano, Ana, et al.
Publicado: (2012)

Transcriptional network orchestrating regional patterning of cortical progenitors
por: Ypsilanti, Athéna R., et al.
Publicado: (2021)

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility
por: Dogan, Nergiz, et al.
Publicado: (2015)

Molecular control of neuromuscular junction development
por: Ferraro, Elisabetta, et al.
Publicado: (2011)

The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
por: Moresi, Viviana, et al.
Publicado: (2019)

Single-cell, whole-embryo phenotyping of mammalian developmental disorders
por: Huang, Xingfan, et al.
Publicado: (2023)

Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
por: He, Aibin, et al.
Publicado: (2014)

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations
por: Ramaker, Ryne C., et al.
Publicado: (2020)

Sources for skeletal muscle repair: from satellite cells to reprogramming
por: Sirabella, Dario, et al.
Publicado: (2013)

Akt-mediated phosphorylation controls the activity of the Y-box protein MSY3 in skeletal muscle
por: De Angelis, Luciana, et al.
Publicado: (2015)

Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps
por: Mortazavi, Ali, et al.
Publicado: (2013)

Mapping and modeling the genomic basis of differential RNA isoform expression at single-cell resolution with LR-Split-seq
por: Rebboah, Elisabeth, et al.
Publicado: (2021)

Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses
por: Wilkinson, Adam C., et al.
Publicado: (2013)

Mining gene expression data by interpreting principal components
por: Roden, Joseph C, et al.
Publicado: (2006)

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice
por: Haigh, Jessica L., et al.
Publicado: (2021)

A mathematical and computational framework for quantitative comparison and integration of large-scale gene expression data
por: Hart, Christopher E., et al.
Publicado: (2005)

Epigenetic Regulation Shapes the Stem Cells State
por: Caretti, Giuseppina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_73s8dqkq7n6dl9rd088ttokt6t