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When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension
Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and part of their fundamental role is also the regula...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410919/ https://www.ncbi.nlm.nih.gov/pubmed/32850883 http://dx.doi.org/10.3389/fmed.2020.00352 |
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author | Bhagwani, Aneel Thompson, A. A. Roger Farkas, Laszlo |
author_facet | Bhagwani, Aneel Thompson, A. A. Roger Farkas, Laszlo |
author_sort | Bhagwani, Aneel |
collection | PubMed |
description | Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and part of their fundamental role is also the regulation of immune function and inflammation. In this review, we summarize the current knowledge of how Toll-like receptors contribute to the immune and non-immune functions of the endothelial cells. |
format | Online Article Text |
id | pubmed-7410919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74109192020-08-25 When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension Bhagwani, Aneel Thompson, A. A. Roger Farkas, Laszlo Front Med (Lausanne) Medicine Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and part of their fundamental role is also the regulation of immune function and inflammation. In this review, we summarize the current knowledge of how Toll-like receptors contribute to the immune and non-immune functions of the endothelial cells. Frontiers Media S.A. 2020-07-31 /pmc/articles/PMC7410919/ /pubmed/32850883 http://dx.doi.org/10.3389/fmed.2020.00352 Text en Copyright © 2020 Bhagwani, Thompson and Farkas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bhagwani, Aneel Thompson, A. A. Roger Farkas, Laszlo When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title | When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title_full | When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title_fullStr | When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title_full_unstemmed | When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title_short | When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension |
title_sort | when innate immunity meets angiogenesis—the role of toll-like receptors in endothelial cells and pulmonary hypertension |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410919/ https://www.ncbi.nlm.nih.gov/pubmed/32850883 http://dx.doi.org/10.3389/fmed.2020.00352 |
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