Cargando…

Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in multiple cancers including colorectal cancer; however, it is unclear whether uptake of exogeneous fatty acids can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drury, James, Rychahou, Piotr G., He, Daheng, Jafari, Naser, Wang, Chi, Lee, Eun Y., Weiss, Heidi L., Evers, Bernard Mark, Zaytseva, Yekaterina Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411002/ https://www.ncbi.nlm.nih.gov/pubmed/32850342 http://dx.doi.org/10.3389/fonc.2020.01185

Ejemplares similares

Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression
por: Drury, James, et al.
Publicado: (2022)

Activation of c-Met and Upregulation of CD44 Expression Are Associated with the Metastatic Phenotype in the Colorectal Cancer Liver Metastasis Model
por: Elliott, Victoria A., et al.
Publicado: (2014)

Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration
por: Zaytseva, Yekaterina Y., et al.
Publicado: (2015)

Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
por: Sinner, Heather F., et al.
Publicado: (2019)

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer
por: Drury, James, et al.
Publicado: (2022)

Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer
por: Xiong, Xiaopeng, et al.
Publicado: (2020)

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer
por: Zaytseva, Yekaterina Y., et al.
Publicado: (2018)

Colorectal cancer lung metastasis treatment with polymer–drug nanoparticles
por: Rychahou, Piotr, et al.
Publicado: (2018)

Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
por: Guo, Yubin, et al.
Publicado: (2020)

Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis
por: Liu, Jianyu, et al.
Publicado: (2008)

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer
por: Wen, Yang-An, et al.
Publicado: (2017)

SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation
por: Li, Chang, et al.
Publicado: (2020)

Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling
por: Rock, Stephanie, et al.
Publicado: (2019)

Role of AMPK and Akt in triple negative breast cancer lung colonization
por: Johnson, Jeremy, et al.
Publicado: (2021)

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
por: Wen, Yang-An, et al.
Publicado: (2018)

Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer
por: Johnson, Jeremy, et al.
Publicado: (2020)

Lipid Metabolism as a Targetable Metabolic Vulnerability in Colorectal Cancer
por: Zaytseva, Yekaterina
Publicado: (2021)

Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers
por: Johnson, Jeremy, et al.
Publicado: (2019)

TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
por: Zhou, Y, et al.
Publicado: (2015)

The role of talin2 in breast cancer tumorigenesis and metastasis
por: Li, Liqing, et al.
Publicado: (2017)

Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation
por: Li, Chang, et al.
Publicado: (2022)

NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation
por: Wang, Q, et al.
Publicado: (2013)

Upregulation of fatty acid synthase in MYC and BCL-2 double-expressor lymphoma
por: Zhong, Xing, et al.
Publicado: (2021)

HER2 upregulates fatty acid synthase and acetyl-CoA carboxylase at a translational level in breast cancer cells
por: Yoon, S, et al.
Publicado: (2005)

The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis
por: Durham, Jerika, et al.
Publicado: (2023)

Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis
por: Lee, Kyung Ha, et al.
Publicado: (2017)

Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells
por: Zaytseva, Yekaterina Y, et al.
Publicado: (2008)

Transcription factor NF-YA promotes a malignant phenotype by upregulating fatty acid synthase expression
por: Guo, Jing, et al.
Publicado: (2016)

Lymphocytes upregulate CD36 in adipose tissue and liver
por: Couturier, Jacob, et al.
Publicado: (2019)

Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer
por: Tian, Shenghua, et al.
Publicado: (2018)

PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors
por: Chow, Zeta, et al.
Publicado: (2021)

The Exocyst Is Required for CD36 Fatty Acid Translocase Trafficking and Free Fatty Acid Uptake in Skeletal Muscle Cells
por: Nakamura, Nicole K., et al.
Publicado: (2022)

Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase
por: Lou, Jennifer W., et al.
Publicado: (2020)

The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36
por: Zhou, Bing, et al.
Publicado: (2020)

Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues
por: Myers, Jennifer S., et al.
Publicado: (2016)

α-Linolenic Acid Suppresses Proliferation and Invasion in Osteosarcoma Cells via Inhibiting Fatty Acid Synthase
por: Fan, Huijin, et al.
Publicado: (2022)

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat
por: Hasan, S. M. Naimul, et al.
Publicado: (2023)

Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling
por: Li, Chaohao, et al.
Publicado: (2023)

Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase
por: Lin, Chia-Der, et al.
Publicado: (2011)

Fatty Acid Synthase as a Factor Required for Exercise-Induced Cognitive Enhancement and Dentate Gyrus Cellular Proliferation
por: Chorna, Nataliya E., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_oi5fr9k3l0dne0a0gkplf2ak1s