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Sibling validation of polygenic risk scores and complex trait prediction

We test 26 polygenic predictors using tens of thousands of genetic siblings from the UK Biobank (UKB), for whom we have SNP genotypes, health status, and phenotype information in late adulthood. Siblings have typically experienced similar environments during childhood, and exhibit negligible populat...

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Detalles Bibliográficos
Autores principales:	Lello, Louis, Raben, Timothy G., Hsu, Stephen D. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411027/ https://www.ncbi.nlm.nih.gov/pubmed/32764582 http://dx.doi.org/10.1038/s41598-020-69927-7

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