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Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis

Toxoplasmosis is one of the most prevalent infections in humans and animals caused by the intracellular protozoan parasite Toxoplasma gondii (T. gondii). Rodents, as intermediate and reservoir hosts, play a key role in the maintenance and transmission of T. gondii. They can be contaminated and maint...

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Autores principales: Galeh, Tahereh Mikaeili, Sarvi, Shahabeddin, Montazeri, Mahbobeh, Moosazadeh, Mahmood, Nakhaei, Maryam, Shariatzadeh, Seyyed Ali, Daryani, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411222/
https://www.ncbi.nlm.nih.gov/pubmed/32851037
http://dx.doi.org/10.3389/fvets.2020.00461
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author Galeh, Tahereh Mikaeili
Sarvi, Shahabeddin
Montazeri, Mahbobeh
Moosazadeh, Mahmood
Nakhaei, Maryam
Shariatzadeh, Seyyed Ali
Daryani, Ahmad
author_facet Galeh, Tahereh Mikaeili
Sarvi, Shahabeddin
Montazeri, Mahbobeh
Moosazadeh, Mahmood
Nakhaei, Maryam
Shariatzadeh, Seyyed Ali
Daryani, Ahmad
author_sort Galeh, Tahereh Mikaeili
collection PubMed
description Toxoplasmosis is one of the most prevalent infections in humans and animals caused by the intracellular protozoan parasite Toxoplasma gondii (T. gondii). Rodents, as intermediate and reservoir hosts, play a key role in the maintenance and transmission of T. gondii. They can be contaminated and maintain the parasite in the form of cysts in their bodies, demonstrating an infection source for their offsprings, predators (particularly felids), and other animals. Therefore, the present systematic review and meta-analysis study was carried out to evaluate the global seroprevalence of T. gondii in these mammals. For achieving the purpose of the current study, six English databases (PubMed, Science Direct, Web of Science, Scopus, ProQuest, and Google Scholar) were systematically searched for related studies from 1970 to 2018. Finally, a total of 52,372 records were screened, 105 records including 26,221 rodents were incorporated in the present study. By random effect models, the overall seroprevalence was calculated at 6% (95% CI = 6–7%), with the highest amount was observed in Africa (24%) and South America (18%), and the lowest amount in Europe (1%). The subgroup data analysis by gender manifested that the prevalence of Immunoglobulin G antibodies did not differ between genders (P > 0.05). Due to the significant heterogeneity, meta-regression models were applied based on serological techniques and continental regions; however, the obtained values were not statistically significant (P = 0.480 and P = 0.295, respectively). The present study revealed a relatively low level of T. gondii seroprevalence in rodents; however, if they were the main food source for their predators, they would cause high transmission of T. gondii.
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spelling pubmed-74112222020-08-25 Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis Galeh, Tahereh Mikaeili Sarvi, Shahabeddin Montazeri, Mahbobeh Moosazadeh, Mahmood Nakhaei, Maryam Shariatzadeh, Seyyed Ali Daryani, Ahmad Front Vet Sci Veterinary Science Toxoplasmosis is one of the most prevalent infections in humans and animals caused by the intracellular protozoan parasite Toxoplasma gondii (T. gondii). Rodents, as intermediate and reservoir hosts, play a key role in the maintenance and transmission of T. gondii. They can be contaminated and maintain the parasite in the form of cysts in their bodies, demonstrating an infection source for their offsprings, predators (particularly felids), and other animals. Therefore, the present systematic review and meta-analysis study was carried out to evaluate the global seroprevalence of T. gondii in these mammals. For achieving the purpose of the current study, six English databases (PubMed, Science Direct, Web of Science, Scopus, ProQuest, and Google Scholar) were systematically searched for related studies from 1970 to 2018. Finally, a total of 52,372 records were screened, 105 records including 26,221 rodents were incorporated in the present study. By random effect models, the overall seroprevalence was calculated at 6% (95% CI = 6–7%), with the highest amount was observed in Africa (24%) and South America (18%), and the lowest amount in Europe (1%). The subgroup data analysis by gender manifested that the prevalence of Immunoglobulin G antibodies did not differ between genders (P > 0.05). Due to the significant heterogeneity, meta-regression models were applied based on serological techniques and continental regions; however, the obtained values were not statistically significant (P = 0.480 and P = 0.295, respectively). The present study revealed a relatively low level of T. gondii seroprevalence in rodents; however, if they were the main food source for their predators, they would cause high transmission of T. gondii. Frontiers Media S.A. 2020-07-31 /pmc/articles/PMC7411222/ /pubmed/32851037 http://dx.doi.org/10.3389/fvets.2020.00461 Text en Copyright © 2020 Galeh, Sarvi, Montazeri, Moosazadeh, Nakhaei, Shariatzadeh and Daryani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Galeh, Tahereh Mikaeili
Sarvi, Shahabeddin
Montazeri, Mahbobeh
Moosazadeh, Mahmood
Nakhaei, Maryam
Shariatzadeh, Seyyed Ali
Daryani, Ahmad
Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title_full Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title_fullStr Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title_full_unstemmed Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title_short Global Status of Toxoplasma gondii Seroprevalence in Rodents: A Systematic Review and Meta-Analysis
title_sort global status of toxoplasma gondii seroprevalence in rodents: a systematic review and meta-analysis
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411222/
https://www.ncbi.nlm.nih.gov/pubmed/32851037
http://dx.doi.org/10.3389/fvets.2020.00461
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