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Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy

Sirtuin 1 (SIRT1) is involved in the pathogenesis of allergic asthma. This study aimed to investigate whether EX-527, a specific SIRT1 inhibitor, exerted suppressive effects on allergic airway inflammation in mice submitted to ovalbumin (OVA) inhalation. In addition, this study assessed whether such...

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Detalles Bibliográficos
Autores principales:	Wu, Yuanyuan, Li, Wei, Hu, Yifan, Liu, Yun, Sun, Xiuzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411491/ https://www.ncbi.nlm.nih.gov/pubmed/32705226 http://dx.doi.org/10.3892/mmr.2020.11338

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