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μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve

Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each e...

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Autores principales: Dieter, Alexander, Klein, Eric, Keppeler, Daniel, Jablonski, Lukasz, Harczos, Tamas, Hoch, Gerhard, Rankovic, Vladan, Paul, Oliver, Jeschke, Marcus, Ruther, Patrick, Moser, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411546/
https://www.ncbi.nlm.nih.gov/pubmed/32596983
http://dx.doi.org/10.15252/emmm.202012387
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author Dieter, Alexander
Klein, Eric
Keppeler, Daniel
Jablonski, Lukasz
Harczos, Tamas
Hoch, Gerhard
Rankovic, Vladan
Paul, Oliver
Jeschke, Marcus
Ruther, Patrick
Moser, Tobias
author_facet Dieter, Alexander
Klein, Eric
Keppeler, Daniel
Jablonski, Lukasz
Harczos, Tamas
Hoch, Gerhard
Rankovic, Vladan
Paul, Oliver
Jeschke, Marcus
Ruther, Patrick
Moser, Tobias
author_sort Dieter, Alexander
collection PubMed
description Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus‐mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi‐channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin‐film light‐emitting diodes (μLEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of μLED‐based oCIs for spectrally selective activation of the auditory nerve.
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spelling pubmed-74115462020-08-10 μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve Dieter, Alexander Klein, Eric Keppeler, Daniel Jablonski, Lukasz Harczos, Tamas Hoch, Gerhard Rankovic, Vladan Paul, Oliver Jeschke, Marcus Ruther, Patrick Moser, Tobias EMBO Mol Med Articles Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus‐mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi‐channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin‐film light‐emitting diodes (μLEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of μLED‐based oCIs for spectrally selective activation of the auditory nerve. John Wiley and Sons Inc. 2020-06-29 2020-08-07 /pmc/articles/PMC7411546/ /pubmed/32596983 http://dx.doi.org/10.15252/emmm.202012387 Text en © 2020 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Dieter, Alexander
Klein, Eric
Keppeler, Daniel
Jablonski, Lukasz
Harczos, Tamas
Hoch, Gerhard
Rankovic, Vladan
Paul, Oliver
Jeschke, Marcus
Ruther, Patrick
Moser, Tobias
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title_full μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title_fullStr μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title_full_unstemmed μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title_short μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
title_sort μled‐based optical cochlear implants for spectrally selective activation of the auditory nerve
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411546/
https://www.ncbi.nlm.nih.gov/pubmed/32596983
http://dx.doi.org/10.15252/emmm.202012387
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